Bioactive Effects of Curcumin in Human Immunodeficiency Virus Infection Along with the Most Effective Isolation Techniques and Type of Nanoformulations

被引：23

作者：

Butnariu, Monica ^{[1
]}

Quispe, Cristina ^{[2
]}

Koirala, Niranjan ^{[3
,4
]}

Khadka, Sujan ^{[5
,6
]}

Salgado-Castillo, Carla Marina ^{[7
]}

Akram, Muhammad ^{[8
]}

Anum, Rabia ^{[9
]}

Yeskaliyeva, Balakyz

Cruz-Martins, Natalia ^{[10
,11
,12
,13
]}

Martorell, Miquel ^{[14
,15
,16
]}

Kumar, Manoj ^{[17
]}

Bagiu, Radu Vasile ^{[18
,19
]}

Razis, Ahmad Faizal Abdull ^{[20
,21
]}

Sunusi, Usman ^{[21
,22
]}

Kamal, Ramla Muhammad ^{[21
,23
]}

Sharifi-Rad, Javad ^{[7
]}

机构：

[1] Univ Life Sci King Mihai I Timisoara, Chem & Biochem Discipline, Calea Aradului 119, Timis 300645, Romania

[2] Univ Arturo Prat, Fac Ciencias Salud, Iquique 1110939, Chile

[3] Dr Koirala Res Inst Biotechnol & Biodivers, Dept Nat Prod Res, Kathmandu 44600, Nepal

[4] Univ Macau, Fac Sci & Technol, Lab Biotechnol, Macau 999078, Peoples R China

[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[6] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China

[7] Univ Azuay, Fac Med, Cuenca, Ecuador

[8] Govt Coll Univ Faisalabad, Dept Eastern Med, Faisalabad, Pakistan

[9] SINA Hlth Educ & Welf Trust, Karachi, Pakistan

[10] Univ Porto, Fac Med, Porto, Portugal

[11] Univ Porto, Inst Res & Innovat Hlth i3S, Porto, Portugal

[12] Inst Res & Adv Training Hlth Sci & Technol CESPU, P-4585116 Gandra Prd, Portugal

[13] Univ Inst Hlth Sci, TOXRUN Oxicol Res Unit, CESPU, CRL, P-4585116 Gandra, Portugal

[14] Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion 4070386, Chile

[15] Univ Concepcion, Ctr Hlth Living, Concepcion 4070386, Chile

[16] Univ Concepcion, Unidad Desarrollo Tecnol, UDT, Concepcion 4070386, Chile

[17] ICAR Cent Inst Res Cotton Technol, Chem & Biochem Proc Div, Mumbai 400019, India

[18] Victor Babes Univ Med & Pharm Timisoara, Dept Microbiol, Timisoara, Romania

[19] Prevent Med Study Ctr, Timisoara, Romania

[20] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Upm Serdang 43400, Selangor, Malaysia

[21] Univ Putra Malaysia, Inst Biosci, Nat Med & Prod Res Lab, Upm Serdang 43400, Selangor, Malaysia

[22] Bayero Univ Kano, Dept Biochem, Kano, Nigeria

[23] Fed Univ Dutse, Dept Pharmacol, Dutse, Jigawa State, Nigeria

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2022年 / 17卷

关键词：

curcumin; bioactivities; HIV therapy; nanoparticles; nanoformulations; MICROWAVE-ASSISTED EXTRACTION; ANTIRETROVIRAL THERAPY; BIOLOGICAL-ACTIVITIES; HIV-1; INTEGRASE; BREAST-CANCER; UP-REGULATION; NANOPARTICLES; DERIVATIVES; MECHANISMS; INHIBITION;

D O I：

10.2147/IJN.S364501

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Human immunodeficiency virus (HIV) is one of the leading causes of death worldwide, with African countries being the worst affected by this deadly virus. Curcumin (CUR) is a Curcuma longa-derived polyphenol that has attracted the attention of researchers due to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antiviral effects. CUR also demonstrates anti-HIV effects by acting as a possible inhibitor of gp120 binding, integrase, protease, and topoisomerase II activities, besides also exerting a protective action against HIV-associated diseases. However, its effectiveness is limited due to its poor water solubility, rapid metabolism, and systemic elimination. Nanoformulations have been shown to be useful to enhance curcumin's bioavailability and its effectiveness as an anti-HIV agent. In this sense, bioactive effects of CUR in HIV infection are carefully reviewed, along with the most effective isolation techniques and type of nanoformulations available.

引用

页码：3619 / 3632

页数：14

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