Effects of atorvastatin on vascular function, inflammation, and androgens in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial

被引:47
作者
Raja-Khan, Nazia [1 ]
Kunselman, Allen R. [2 ]
Hogeman, Cynthia S. [4 ]
Stetter, Christy M. [2 ]
Demers, Laurence M.
Legro, Richard S. [3 ]
机构
[1] Penn State Univ, Coll Med, Milton S Hershey Med Ctr, Div Endocrinol Diabet & Metab,Dept Med, Hershey, PA 17033 USA
[2] Penn State Univ, Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA
[3] Penn State Univ, Coll Med, Dept Obstet & Gynecol, Hershey, PA 17033 USA
[4] Penn State Univ, Coll Med, Inst Heart & Vasc, Hershey, PA 17033 USA
关键词
Hyperandrogenemia; hyperinsulinemia; PCOS; statin; vascular function; FLOW-MEDIATED VASODILATATION; BRACHIAL-ARTERY; ENDOTHELIAL FUNCTION; SIMVASTATIN; DYSLIPIDEMIA;
D O I
10.1016/j.fertnstert.2010.11.040
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
To determine the effects of statins on vascular function, inflammation, and androgen levels in women with polycystic ovary syndrome (PCOS), we randomized 20 women with PCOS who had low-density lipoprotein cholesterol levels >100 mg/dL to atorvastatin (40 mg/day) or placebo for 6 weeks and found that atorvastatin reduced androgen levels, biomarkers of inflammation, and blood pressure; increased insulin levels and brachial artery conductance during reactive hyperemia; and failed to improve brachial artery flow-mediated dilation. We conclude that until additional studies demonstrate a clear risk-to-benefit ratio favoring statin therapy in PCOS, statins should only be used in women with PCOS who meet current indications for statin treatment. (Fertil Steril (R) 2011;95:1849-52. (C)2011 by American Society for Reproductive Medicine.)
引用
收藏
页码:1849 / 1852
页数:4
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