The role of the Cdk5-p35 kinase in neuronal development

被引：28

作者：

Paglini, G ^{[1
]}

Cáceres, A ^{[1
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, INIMEC, Inst Invest Med Mercedes & Martin Ferreyra, RA-5000 Cordoba, Argentina

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 2001年 / 268卷 / 06期

关键词：

Cdk5; p35; neuronal migration; axons; growth cones; cytoskeleton; MAP1B; PAK1; beta-catenin; cables;

D O I：

10.1046/j.1432-1033.2001.02023.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclin-dependent kinase 5 (Cdk5) plays a key role in proper development of the nervous system. To be activated, Cdk5 associates with regulatory subunits not related to cyclins, such as p35 (the regulatory subunit of Cdk5). In this article, we review some of the experimental evidence supporting a central role for the Cdk5/p35 kinase in neuronal migration and process formation.

引用

页码：1528 / 1533

页数：6

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