Minimal invasive fixation following with radiotherapy for radiosensitive unstable metastatic spine

Background: Minimally invasive surgery (MIS) has become a feasible option for patients with spinal metastasis, but the effectiveness of percutaneous pedicle screw fixation (PPSF) without decompression in patients with severe cord compression remains unknown. We compared PPSF without decompression with debulking surgery in patients with radio-sensitive, unstable, metastatic thoracolumbar spinal cord compression. Methods: A retrospective study of surgically treated spinal metastasis and spinal cord compression patients was conducted between October 2014 and June 2019. Demographic and pre-and postoperative data were collected and compared between patients treated with minimally invasive percutaneous fixation and external beam radiotherapy (EBRT) (the PPSF group) and those treated with debulking surgery (the debulking group). Results: We included 50 patients in this study. The PPSF group had a significantly shorter operative time (143.56 +/- 49.44 min vs. 181.47 +/- 40.77 min; p < 0.01), significantly lower blood loss (116.67 +/- 109.92 mL vs. 696.55 +/- 519.43 mL; p < 0.01), and significantly shorter hospital stay (11.90 +/- 9.69 vs. 25.35 +/- 20.65; p < 0.01) than did the debulking group. No significant differences were observed between the groups in age, sex, spinal instability neoplastic score, ESCC, Tomita scores, numeric rating scale scores, American Spinal Injury Associa-tion Impairment Scale scores, survival rates, and complication rates. Postoperative neurologic function and decrease in pain were similar between the groups. Conclusion: The PPSF group had a shorter operation time, shorter length of hospital stay, and less blood loss than did the debulking group. PPSF followed by EBRT is pain relieving, relatively safe and appropriate as palliative therapy.