Novel Antibacterial Targets in Protein Biogenesis Pathways

被引：5

作者：

Potteth, Upasana S. ^{[1
]}

Upadhyay, Tulsi ^{[1
]}

Saini, Snehlata ^{[1
]}

Saraogi, Ishu ^{[1
,2
]}

机构：

[1] Indian Inst Sci Educ & Res Bhopal, Dept Biol Sci, Bhopal Bypass Rd, Bhopal 462066, Madhya Pradesh, India

[2] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal Bypass Rd, Bhopal 462066, Madhya Pradesh, India

来源：

CHEMBIOCHEM | 2022年 / 23卷 / 04期

关键词：

antibiotic resistance; chaperone proteins; inhibitors; protein folding; protein transport; SIGNAL-RECOGNITION PARTICLE; HEAT-SHOCK PROTEINS; ESCHERICHIA-COLI; SMALL-MOLECULE; METHIONINE AMINOPEPTIDASES; CRYSTAL-STRUCTURE; TRIGGER FACTOR; SEQUENCE RECOGNITION; STRUCTURAL-ANALYSIS; CHAPERONE MACHINE;

D O I：

10.1002/cbic.202100459

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibiotic resistance has emerged as a global threat due to the ability of bacteria to quickly evolve in response to the selection pressure induced by anti-infective drugs. Thus, there is an urgent need to develop new antibiotics against resistant bacteria. In this review, we discuss pathways involving bacterial protein biogenesis as attractive antibacterial targets since many of them are essential for bacterial survival and virulence. We discuss the structural understanding of various components associated with bacterial protein biogenesis, which in turn can be utilized for rational antibiotic design. We highlight efforts made towards developing inhibitors of these pathways with insights into future possibilities and challenges. We also briefly discuss other potential targets related to protein biogenesis.

引用

页数：19

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