Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischemic brain stroke: their molecular targets and action mechanisms

被引：61

作者：

Choi, Dong-Young ^{[1
]}

Choi, Hyukjae ^{[1
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Gyeongbuk 712749, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2015年 / 38卷 / 02期

关键词：

Marine natural products; Neurological diseases; Neuroprotective; Alzheimer's disease; Parkinson's disease; Ischemic brain stroke; NICOTINIC ACETYLCHOLINE-RECEPTORS; GAMMA-SECRETASE INHIBITOR; 13-DESMETHYL SPIROLIDE-C; ALPHA-CONOTOXIN BUIA; SPONGE RENIERA-SARAI; METHYL-D-ASPARTATE; PENICILLIUM-CITRINUM SPI080624G1F01; ADENOSINE KINASE INHIBITOR; CALCIUM-CHANNEL SUBTYPES; FOCAL CEREBRAL-ISCHEMIA;

D O I：

10.1007/s12272-014-0503-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Continuous increases in the incidence of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and brain stroke demand the urgent development of therapeutics. Marine organisms are well-known producers of natural products with diverse structures and pharmacological activities. Therefore, researchers have endeavored to identify marine natural products with neuroprotective effects. In this regard, this review summarizes therapeutic targets for AD, PD, and ischemic brain stroke and marine natural products with pharmacological activities on the targets according to taxonomies of marine organisms. Furthermore, several marine natural products on the clinical trials for the treatment of neurological disorders are discussed.

引用

页码：139 / 170

页数：32

共 296 条

[1]

ABOU-CHAAR C I, 1980, Quarterly Journal of Crude Drug Research, V18, P49

[2] A Phase II study targeting amyloid-β with 3APS in mild-to-moderate Alzheimer disease [J].

Aisen, P. S. ;

Saumier, D. ;

Briand, R. ;

Laurin, J. ;

Gervais, F. ;

Tremblay, P. ;

Garceau, D. .

NEUROLOGY, 2006, 67 (10) :1757-1763

[3] Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study) [J].

Aisen, Paul S. ;

Gauthier, Serge ;

Ferris, Steven H. ;

Saumier, Daniel ;

Haine, Denis ;

Garceau, Denis ;

Anh Duong ;

Suhy, Joyce ;

Oh, Joonmi ;

Lau, Wan C. ;

Sampalis, John .

ARCHIVES OF MEDICAL SCIENCE, 2011, 7 (01) :102-111

[4] Neoechinulin A Impedes the Progression of Rotenone-Induced Cytotoxicity in PC12 Cells [J].

Akashi, Soichiro ;

Kimura, Tomonori ;

Takeuchi, Toshifumi ;

Kuramochi, Kouji ;

Kobayashi, Susumu ;

Sugawara, Fumio ;

Watanabe, Nobuo ;

Arai, Takao .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2011, 34 (02) :243-248

[5] PALINURIN, A NEW LINEAR SESTERTERPENE FROM A MARINE SPONGE [J].

ALFANO, G ;

CIMINO, G ;

DESTEFANO, S .

EXPERIENTIA, 1979, 35 (09) :1136-1137

[6] The major determinant of the heparin binding of glial cell-line-derived neurotrophic factor is near the N-terminus and is dispensable for receptor binding [J].

Alfano, Ivan ;

Vora, Parvez ;

Mummery, Rosemary S. ;

Mulloy, Barbara ;

Rider, Christopher C. .

BIOCHEMICAL JOURNAL, 2007, 404 (01) :131-140

[7] Translocation of PKC by Yessotoxin in an in Vitro Model of Alzheimer's Disease with Improvement of Tau and β-Amyloid Pathology [J].

Alonso, Eva ;

Vale, Carmen ;

Vieytes, Mercedes R. ;

Botana, Luis M. .

ACS CHEMICAL NEUROSCIENCE, 2013, 4 (07) :1062-1070

[8] Benefit of 13-desmethyl Spirolide C Treatment in Triple Transgenic Mouse Model of Alzheimer Disease: Beta-Amyloid and Neuronal Markers Improvement [J].

Alonso, Eva ;

Otero, Paz ;

Vale, Carmen ;

Alfonso, Amparo ;

Antelo, Alvaro ;

Gimenez-Llort, Lydia ;

Chabaud, Laurent ;

Guillou, Catherine ;

Botana, Luis M. .

CURRENT ALZHEIMER RESEARCH, 2013, 10 (03) :279-289

[9] Design and Synthesis of Skeletal Analogues of Gambierol: Attenuation of Amyloid-β and Tau Pathology with Voltage-Gated Potassium Channel and N-Methyl-D-aspartate Receptor Implications [J].

Alonso, Eva ;

Fuwa, Haruhiko ;

Vale, Carmen ;

Suga, Yuto ;

Goto, Tomomi ;

Konno, Yu ;

Sasaki, Makoto ;

LaFerla, Frank M. ;

Vieytes, Mercedes R. ;

Gimenez-Llort, Lydia ;

Botana, Luis M. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (17) :7467-7479

[10] 13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro [J].

Alonso, Eva ;

Vale, Carmen ;

Vieytes, Mercedes R. ;

Laferla, Frank M. ;

Gimenez-Llort, Lydia ;

Botana, Luis M. .

NEUROCHEMISTRY INTERNATIONAL, 2011, 59 (07) :1056-1065

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