A fast cardiac gamma camera with dynamic SPECT capabilities: design, system validation and future potential

被引:225
作者
Bocher, Moshe [1 ]
Blevis, Ira M. [2 ]
Tsukerman, Leonid [2 ]
Shrem, Yigal [2 ]
Kovalski, Gil [2 ]
Volokh, Lana [2 ]
机构
[1] Hebrew Univ Jerusalem, Hadassah Hosp, Jerusalem, Israel
[2] GE Healthcare, Mol Imaging, Tirat Karmel, Israel
关键词
Cardiac gamma camera; Single photon emission computed tomography; Myocardial perfusion scintigraphy; Discovery NM 530c; CORONARY-ARTERY-DISEASE; EMISSION COMPUTED-TOMOGRAPHY; MYOCARDIAL-PERFUSION SPECT; TECHNETIUM 99M-LABELED TEBOROXIME; SMALL-ANIMAL SPECT; FLOW RESERVE; BLOOD-FLOW; RADIONUCLIDE ANGIOCARDIOGRAPHY; MULTIPINHOLE SPECT; NUCLEAR CARDIOLOGY;
D O I
10.1007/s00259-010-1488-z
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The goal of this study is to present the Discovery NM 530c (DNM), a cardiac SPECT camera, interfacing multi-pinhole collimators with solid-state modules, aiming at slashing acquisition time without jeopardizing quality. DNM resembles PET since it enables 3-D SPECT without detector motion. We further envision how these novel capabilities may help with current and future challenges of cardiac imaging. DNM sensitivity, spatial resolution (SR) and energy resolution (ER), count rate response, cardiac uniformity and cardiac defect contrast were measured and compared to a dedicated cardiac, dual-head standard SPECT (S-SPECT) camera. DNM sensitivity was more than threefold higher while SR was notably better. Significantly, SR was the same for Tc-99m and Tl-201. ER was improved on DNM and allowed good separation of Tc-99m and I-123 spectral peaks. Count rate remained linear on DNM up to 612 kcps, while S-SPECT showed severe dead time limitations. Phantom studies revealed comparable uniformity and defect contrast, notwithstanding significantly shorter acquisition time for the DNM. First patient images, including dynamic SPECT, are also presented. DNM is raising the bar for expedition and upgrade of practice. It features high sensitivity as well as improved SR, temporal resolution and ER. It enables reduction of acquisition time and fast protocols. Importantly, it is potentially capable of dynamic 3-D acquisition. The new technology is potentially upgradeable and may become a milestone in the evolution of nuclear cardiology as it assumes its key role in molecular imaging of the heart.
引用
收藏
页码:1887 / 1902
页数:16
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