Quantitative analysis of enalapril by 1H NMR spectroscopy in tablets

被引：31

作者：

Zoppi, A ^{[1
]}

Linares, M ^{[1
]}

Longhi, M ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farm, RA-5000 Cordoba, Argentina

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2005年 / 37卷 / 03期

关键词：

enalapril; H-1 NMR spectroscopy;

D O I：

10.1016/j.jpba.2004.11.027

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple, rapid, accurate and selective H-1 NMR method was developed for quantitative determination of enalapril maleate in pharmaceutical preparations. Spectra were determined in D2O, using L-leucine as internal standard. Both synthetic mixtures and commercial dosage forms were assayed. and the results were compared to those obtained using the USP XXIV procedure and were both in close agreement. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：627 / 630

页数：4

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