Effect of Lactobacillus paracasei subsp paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study

被引：72

作者：

Jespersen, Lillian ^{[1
]}

Tarnow, Inge ^{[1
]}

Eskesen, Dorte ^{[1
]}

Morberg, Cathrine Melsaether ^{[1
]}

Michelsen, Birgit ^{[1
]}

Buegel, Susanne ^{[2
]}

Dragsted, Lars Ove ^{[2
]}

Rijkers, Ger T. ^{[3
]}

Calder, Philip C. ^{[4
,5
,6
]}

机构：

[1] Chr Hansen AS, DK-2970 Horsholm, Denmark

[2] Univ Copenhagen, Dept Nutr Exercise & Sports, Fac Sci, Copenhagen, Denmark

[3] Roosevelt Acad, Dept Sci, Middelburg, Netherlands

[4] Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton SO9 5NH, Hants, England

[5] Univ Hosp Southampton Natl Hlth Serv Fdn Trust, Natl Inst Hlth Res Southampton Biomed Res Ctr, Southampton, Hants, England

[6] Univ Southampton, Southampton, Hants, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2015年 / 101卷 / 06期

关键词：

immune function; probiotics; upper respiratory tract infection; Lactobacillus paracasei subsp paracasei; vaccination response; L; casei; 431; ANIMALIS SSP LACTIS; PROBIOTICS; INFLAMMATION; BB-12(R); EFFICACY;

D O I：

10.3945/ajcn.114.103531

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Probiotics can modulate the immune system in healthy individuals and may help reduce symptoms related to respiratory infections. Objective: The objective of the study was to investigate the effect of the probiotic strain Lactobacillus paracasei subsp. paracasei, L. casei 431 (Chr. Hansen NS) (hereafter, L. casei 431) on immune response to influenza vaccination and respiratory symptoms in healthy adults. Design: A randomized double-blind, placebo-controlled trial was conducted in 1104 healthy subjects aged 18-60 y at 2 centers in Germany and Denmark. Subjects were randomly assigned to receive an acidified milk drink containing >= 10(9) colony-forming units of L. casei 431 (n = 553) or placebo (n = 551) for 42 d. After 21 d, subjects received the seasonal influenza vaccination. The primary outcome was seroprotection rate (anti-influenza antibody titers by hemagglutination inhibition) 21 d after vaccination. Other outcomes were seroconversion rate and mean titers, influenza A specific antibodies and incidence, and duration and severity of upper respiratory symptoms. Antibiotic use and use of health care resources were recorded. Results: There was no effect of L. casei 431 on immune responses to influenza vaccination. Generalized linear mixed modeling showed a shorter duration of upper respiratory symptoms in the probiotic group than in the placebo group (mean +/- SD: 6.4 +/- 6.1 vs. 7.3 +/- 9.7 d, P = 0.0059) in the last 3 wk of the intervention period. No statistically significant differences were found for incidence or severity. Conclusions: Daily consumption of L. casei 431 resulted in no observable effect on the components of the immune response to influenza vaccination but reduced the duration of upper respiratory symptoms. The trial was registered at www.isrctn.com as ISRCTN08280229.

引用

页码：1188 / 1196

页数：9

共 38 条

[1] Guidance on the scientific requirements for health claims related to gut and immune function EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) [J].