Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling

被引：13

作者：

Haywood, Tom ^{[1
]}

Cesarec, Sara ^{[1
]}

Kealey, Steven ^{[1
]}

Plisson, Christophe ^{[2
]}

Miller, Philip W. ^{[1
]}

机构：

[1] Imperial Coll London, Dept Chem, London SW7 2AZ, England

[2] Imanova Ltd, Imperial Coll London, Hammersmith Hosp, Burlington Danes Bldg,Du Cane Rd, London W12 0NN, England

来源：

MEDCHEMCOMM | 2018年 / 9卷 / 08期

基金：

英国工程与自然科学研究理事会;

关键词：

POSITRON-EMISSION-TOMOGRAPHY; PET; RADIOPHARMACEUTICALS; RADIOCHEMISTRY; THIOCYANATE; TANAPROGET; CHEMISTRY; DISEASE; REAGENT; F-18;

D O I：

10.1039/c7md00425g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein we report the preparation of ammonium [C-11]thiocyanate via the reaction of [C-11]CS2 with ammonia. The [C-11]SCN- ion is demonstrated as a potent nucleophile that can be used to readily generate a range of C-11-labelled thiocyanate molecules in high conversions. Furthermore, novel C-11-labelled thiazolone molecules can be easily prepared from the intermediate alpha-thiocyanatophenones via an acid mediated cyclisation reaction.

引用

页码：1311 / 1314

页数：4

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