Galectins - Potential targets for cancer therapy

被引：57
作者：
Hasan, Syed Saif
Ashraf, Ghulam Md.
Banu, Naheed
机构：
[1] Natl Ctr Cell Sci, Mol Biol Unit, Pune 411007, Maharashtra, India
[2] Aligarh Muslim Univ, Fac Life Sci, Dept Biochem, Aligarh 202002, Uttar Pradesh, India
来源：
CANCER LETTERS | 2007年 / 253卷 / 01期
关键词：
galectins; cancer; metastasis; glycoconjugates; detection; inhibition; therapy;
D O I：
10.1016/j.canlet.2006.11.030
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Galectins are a family of galactose binding lectins that have become the focus of attention of cancer biologists due to their numerous regulatory roles in normal cellular metabolism and also because of their altered levels in various cancers. They are reportedly similar to several prominent and established modulators of apoptosis. In this review, we present a brief outline of the advancements in the methodology used to detect and identify them and their therapeutic applications in cancer. Their possible interactions with other glycoconjugates are also discussed and a vision for their future use in diagnosis and therapeutics is provided. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
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页码：25 / 33
页数：9
相关论文
共 117 条
[1]  
ACKERMAN SJ, 1993, J IMMUNOL, V150, P456
[2]   Biphasic modulation of cell growth by recombinant human galectin-1 [J].
Adams, L ;
Scott, GK ;
Weinberg, CS .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1996, 1312 (02) :137-144
[3]   Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands [J].
Arnusch, CJ ;
André, S ;
Valentini, P ;
Lensch, M ;
Russwurm, R ;
Siebert, HC ;
Fischer, MJE ;
Gabius, HJ ;
Pieters, RJ .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (06) :1437-1440
[4]   GALECTINS - A FAMILY OF ANIMAL BETA-GALACTOSIDE-BINDING LECTINS [J].
BARONDES, SH ;
CASTRONOVO, V ;
COOPER, DNW ;
CUMMINGS, RD ;
DRICKAMER, K ;
FEIZI, T ;
GITT, MA ;
HIRABAYASHI, J ;
HUGHES, C ;
KASAI, K ;
LEFFLER, H ;
LIU, FT ;
LOTAN, R ;
MERCURIO, AM ;
MONSIGNY, M ;
PILLAI, S ;
POIRER, F ;
RAZ, A ;
RIGBY, PWJ ;
RINI, JM ;
WANG, JL .
CELL, 1994, 76 (04) :597-598
[5]  
BARONDES SH, 1994, J BIOL CHEM, V269, P20807
[6]   Galectins: A personal overview [J].
Barondes, SH .
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 1997, 9 (45) :1-7
[7]   Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes [J].
Bernerd, F ;
Sarasin, A ;
Magnaldo, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11329-11334
[8]   Metastasis of human colon cancer is altered by modifying expression of the β-galactoside-binding protein galectin 3 [J].
Bresalier, RS ;
Mazurek, N ;
Sternberg, LR ;
Byrd, JC ;
Yunker, CK ;
Nangia-Makker, P ;
Raz, A .
GASTROENTEROLOGY, 1998, 115 (02) :287-296
[9]   Cross-linking activities of galectins and other multivalent lectins [J].
Brewer, CF .
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 1997, 9 (45) :155-165
[10]   Dual activities of galectin-3 in human prostate cancer:: tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3 [J].
Califice, S ;
Castronovo, V ;
Bracke, M ;
van den Brûle, F .
ONCOGENE, 2004, 23 (45) :7527-7536
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