Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells
被引:236
作者:
Gottschalk, Rachel A.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Dept Immunol, Chevy Chase, MD 20815 USA
Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USA
Gottschalk, Rachel A.
[2
,3
]
Corse, Emily
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Dept Immunol, Chevy Chase, MD 20815 USAMem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USA
Corse, Emily
[2
]
Allison, James P.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USA
Howard Hughes Med Inst, Dept Immunol, Chevy Chase, MD 20815 USAMem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USA
Allison, James P.
[1
,2
]
机构:
[1] Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USA
[2] Howard Hughes Med Inst, Dept Immunol, Chevy Chase, MD 20815 USA
[3] Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Program, New York, NY 10021 USA
The transcription factor Helios has been reported to be a marker of regulatory T cells (Treg) of thymic origin, distinguishing them from Treg induced in the periphery (iTreg). In this study, we demonstrate Helios expression in Foxp3(+) iTreg, both in vitro and in vivo. Following i.v. peptide injection, in vivo Helios expression in adoptively transferred TCR transgenic T cells was more rapid than Foxp3 induction but less stable at later time points without a second injection of peptide. Our in vitro data suggest that APC influence Helios expression in a manner distinct from stimuli required for Foxp3 induction. Thus, Helios expression in iTreg may reflect the context of stimulation during Foxp3 induction. In summary, the robust Helios expression we observe in iTreg precludes its use as a marker of thymic Treg. The Journal of Immunology, 2012, 188: 976-980.
机构:
Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Akimova, Tatiana
;
Beier, Ulf H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Dept Pediat, Div Nephrol, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Beier, Ulf H.
;
Wang, Liqing
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Wang, Liqing
;
Levine, Matthew H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Hosp Univ Penn, Penn Transplant Inst, Dept Surg, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Levine, Matthew H.
;
Hancock, Wayne W.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
机构:
NYU, Sch Med, Mol Pathogenesis Program, Kimmel Ctr Biol & Med,Skirball Inst, New York, NY 10016 USANYU, Sch Med, Mol Pathogenesis Program, Kimmel Ctr Biol & Med,Skirball Inst, New York, NY 10016 USA
de Lafaille, Maria A. Curotto
;
Lafaille, Juan J.
论文数: 0引用数: 0
h-index: 0
机构:NYU, Sch Med, Mol Pathogenesis Program, Kimmel Ctr Biol & Med,Skirball Inst, New York, NY 10016 USA
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
Gottschalk, Rachel A.
;
Corse, Emily
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
Corse, Emily
;
Allison, James P.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Hahm, K
;
Cobb, BS
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h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Cobb, BS
;
McCarty, AS
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机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
McCarty, AS
;
Brown, KE
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h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Brown, KE
;
Klug, CA
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Klug, CA
;
Lee, R
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机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Lee, R
;
Akashi, K
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h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Akashi, K
;
Weissman, IL
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机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Weissman, IL
;
Fisher, AG
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Fisher, AG
;
Smale, ST
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
机构:
Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Akimova, Tatiana
;
Beier, Ulf H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Dept Pediat, Div Nephrol, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Beier, Ulf H.
;
Wang, Liqing
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Wang, Liqing
;
Levine, Matthew H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Philadelphia, PA 19104 USA
Hosp Univ Penn, Penn Transplant Inst, Dept Surg, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Levine, Matthew H.
;
Hancock, Wayne W.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Dept Pathol & Lab Med, Div Transplant Immunol, Philadelphia, PA 19104 USA
机构:
NYU, Sch Med, Mol Pathogenesis Program, Kimmel Ctr Biol & Med,Skirball Inst, New York, NY 10016 USANYU, Sch Med, Mol Pathogenesis Program, Kimmel Ctr Biol & Med,Skirball Inst, New York, NY 10016 USA
de Lafaille, Maria A. Curotto
;
Lafaille, Juan J.
论文数: 0引用数: 0
h-index: 0
机构:NYU, Sch Med, Mol Pathogenesis Program, Kimmel Ctr Biol & Med,Skirball Inst, New York, NY 10016 USA
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
Gottschalk, Rachel A.
;
Corse, Emily
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
Corse, Emily
;
Allison, James P.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Hahm, K
;
Cobb, BS
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Cobb, BS
;
McCarty, AS
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
McCarty, AS
;
Brown, KE
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Brown, KE
;
Klug, CA
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Klug, CA
;
Lee, R
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Lee, R
;
Akashi, K
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Akashi, K
;
Weissman, IL
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Weissman, IL
;
Fisher, AG
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA
Fisher, AG
;
Smale, ST
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA