4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity

被引：3

作者：

Zhou, Fengxu ^{[1
,2
,3
]}

Huang, Ruoyue ^{[4
]}

Cao, Tingting ^{[1
,2
]}

Liu, Jia ^{[1
,2
]}

Yang, Weimin ^{[1
,2
]}

Li, Fei ^{[4
]}

Li, Xian ^{[1
,2
]}

机构：

[1] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650000, Yunnan, Peoples R China

[2] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650000, Yunnan, Peoples R China

[3] Shunde Inst Drug Control, Foshan 528000, Guangdong, Peoples R China

[4] Sichuan Univ, West China Hosp, Chengdu 610041, Sichuan, Peoples R China

来源：

MEDICINAL CHEMISTRY RESEARCH | 2022年 / 31卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Clusiaceae; Mesua ferrea Linn; 4-phenylcoumarin; CYP1B1 inhibitory activity; CYTOTOXIC COUMARINS; CYTOCHROME-P450; ACTIVATION; LIGANDS; CANCER;

D O I：

10.1007/s00044-022-02962-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new 4-phenylcoumarins, mesuaferlinns A-C (1-3), together with ten other known 4-phenylcoumarins, 4-13, were isolated from the branches and leaves of Mesua ferrea Linn (Clusiaceae). The structure of compounds 1-3 were determined on the basis of spectroscopic methods including extensive analysis of NMR and mass spectroscopic data. Ten 4-phenylcoumarins were tested for their cytochrome P450 family 1 enzymes (CYP1A1, CYP1A2, and CYP1B1) inhibitory effects. Compounds 5 and 10 were found to be the most potent two CYP1B1 inhibitors with inhibitory viabilities values of 56.64% and 47.46%, respectively. [GRAPHICS] .

引用

页码：2172 / 2181

页数：10

共 25 条

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