Regioselective synthesis of 1,3,5-substituted pyrazoles from acetylenic ketones and hydrazines

被引：133

作者：

Bishop, BC ^{[1
]}

Brands, KMJ ^{[1
]}

Gibb, AD ^{[1
]}

Kennedy, DJ ^{[1
]}

机构：

[1] Merck Sharp & Dohme Res Labs, Dept Proc Res, Hoddesdon EN11 9BU, Herts, England

来源：

SYNTHESIS-STUTTGART | 2004年 / 01期

关键词：

pyrazoles; ketones; alkynes; hydrazones; regioselectivity;

D O I：

10.1055/s-2003-44376

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of diversely substituted 1,3,5-substituted pyrazoles from the reaction of acetylenic ketones with substituted hydrazines is reported. The reactions were shown to be highly regioselective regardless of the nature of the substituents in the substrates and afforded essentially single pyrazole isomers in excellent yields.

引用

页码：43 / 52

页数：10

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