Inverted replication of vertebrate mitochondria

被引：38

作者：

Fonseca, Miguel M. ^{[1
,2
,3
]}

Posada, David ^{[3
]}

Harris, D. James ^{[1
,2
]}

机构：

[1] Ctr Invest Biodiversidade & Recursos Genet, CiBio UP, Vairao, Portugal

[2] Univ Porto, Fac Ciencias, Dept Zool & Antropol, P-4100 Oporto, Portugal

[3] Univ Vigo, Fac Biol, Dept Bioquim Genet & Immunol, Vigo 36310, Spain

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2008年 / 25卷 / 05期

关键词：

mtDNA; control region; inversion; strand bias; replication mechanism; vertebrates;

D O I：

10.1093/molbev/msn050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After analyzing the base composition asymmetry of coding regions in vertebrate mitochondria, we identified 2 fishes, Albula glossodonta and Bathygadus antrodes, with inverted compositional patterns. Both species appear to have an unusual control region ( CR), and in B. antrodes, it has switched from the light strand to the heavy strand. To our knowledge, this is the first report in vertebrates of inverted mitochondrial replication, caused by an inversion of the CR. These findings support the strand- asymmetric model of mtDNA replication and suggest that vertebrate mtDNA can tolerate globally reversed mutational pressures. In addition, we propose that nucleotide bias is not strand specific but that it depends on the location of the CR.

引用

页码：805 / 808

页数：4

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