How to investigate oxygen supply, uptake, and utilization simultaneously by interleaved NMR imaging and spectroscopy of the skeletal muscle

被引：20
作者：
Carlier, PG
Brillault-Salvat, C
Giacomini, E
Wary, C
Bloch, G
机构：
[1] Univ Paris, Hop La Pitie Salpetriere, Inst Myol, NMR Lab,AFM,IFR14, F-75651 Paris, France
[2] Univ Paris, Hop La Pitie Salpetriere, Inst Myol, CEA,IFR14, F-75651 Paris, France
[3] CEA, SHFJ, F-91406 Orsay, France
来源：
MAGNETIC RESONANCE IN MEDICINE | 2005年 / 54卷 / 04期
关键词：
oxygen; perfusion; myoglobin; skeletal muscle;
D O I：
10.1002/mrm.20649
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Human skeletal muscle perfusion, oxygenation, and high-energy phosphate distribution were measured simultaneously by interleaved H-1 and P-31 NMR spectroscopy and H-1 NMR imaging in vivo. From these parameters, arterial oxygen supply (DO2), muscle reoxygenation rate, mitochondrial ATP production, and O-2 consumption (VO2) were deduced at the recovery phase of a short ischemic exercise bout. In addition, by using a reformulation of the mass conservation law, muscle maximum O-2 extraction was calculated from these parameters.
引用
收藏
页码：1010 / 1013
页数：4
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