The guinea pig as an animal model for asthma

被引：60
作者：
Ricciardolo, Fabio L. M. [1 ]
Nijkamp, Frans [2 ,3 ]
De Rose, Virginia [1 ]
Folkerts, Gert [2 ,3 ]
机构：
[1] Univ Turin, San Luigi Hosp, Clin Pneumol, Dept Clin & Biol Sci,Div Resp Dis, I-10043 Turin, Italy
[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmacol & Pathophysiol, NL-3508 TC Utrecht, Netherlands
[3] Curax BV, Houten, Netherlands
来源：
CURRENT DRUG TARGETS | 2008年 / 9卷 / 06期
关键词：
allergy; asthma; guinea pig; early asthmatic reaction; late asthmatic reaction; airway hyperresponsiveness; airway inflammation; airway remodelling;
D O I：
10.2174/138945008784533534
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Experimental guinea pig asthma is a reliable and clinically relevant facsimile of human disease. The guinea pig is the preferred choice for use as a model of allergic bronchial asthma in the evaluation of anti-asthmatic drugs, since the airway anatomy and the response to inflammatory mediators is similar to humans. Further, the great strength of this model is the direct anaphylactic bronchoconstriction upon antigen challenge. Under certain conditions a late asthmatic response can be measured and airway hyperresponsiveness is observed in vitro and in vivo. Moreover, the inflammatory response is comparable with the human situation. More recent studies describe a chronic model for asthma in which airway remodeling is induced as can be observed in the asthmatic patients. The focus here is to demonstrate that guinea pig asthma models are useful for testing novel therapeutics.
引用
收藏
页码：452 / 465
页数：14
相关论文
共 163 条
[1]  
Alfieri A. B., 2007, Autonomic & Autacoid Pharmacology, V27, P39, DOI 10.1111/j.1474-8673.2006.00388.x
[2]   Early BCG vaccination and development of atopy [J].
Alm, JS ;
Lilja, G ;
Pershagen, G ;
Scheynius, A .
LANCET, 1997, 350 (9075) :400-403
[3]   Heme oxygenase attenuates allergen-induced airway inflammation and hyperreactivity in guinea pigs [J].
Almolki, A ;
Taillé, C ;
Martin, GF ;
Jose, PJ ;
Zedda, C ;
Conti, M ;
Megret, J ;
Henin, D ;
Aubier, M ;
Boczkowski, J .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2004, 287 (01) :L26-L34
[4]   ANTIGEN-INDUCED BRONCHIAL ANAPHYLAXIS IN ACTIVELY SENSITIZED GUINEA-PIGS - PATTERN OF RESPONSE IN RELATION TO IMMUNIZATION REGIMEN [J].
ANDERSSON, P .
ALLERGY, 1980, 35 (01) :65-71
[5]   Animal models to test respiratory allergy of low molecular weight chemicals: A guidance [J].
Arts, Josje H. E. ;
Kuper, C. Frieke .
METHODS, 2007, 41 (01) :61-71
[6]   Detection of superoxide anion released extracellularly by endothelial cells using cytochrome c reduction, ESR, fluorescence and lucigenin-enhanced chemiluminescence techniques [J].
Barbacanne, MA ;
Souchard, JP ;
Darblade, B ;
Iliou, JP ;
Nepveu, F ;
Pipy, B ;
Bayard, F ;
Arnal, JF .
FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (05) :388-396
[7]   EFFICACY AND SAFETY OF INHALED CORTICOSTEROIDS IN ASTHMA - REPORT OF A WORKSHOP HELD IN EZE, FRANCE, OCTOBER 1992 [J].
BARNES, PJ ;
PEDERSEN, S .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (04) :S1-S26
[8]   NITRIC-OXIDE AS AN ENDOGENOUS MODULATOR OF CHOLINERGIC NEUROTRANSMISSION IN GUINEA-PIG AIRWAYS [J].
BELVISI, MG ;
STRETTON, D ;
BARNES, PJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 198 (2-3) :219-221
[9]   NITRIC-OXIDE IS THE ENDOGENOUS NEUROTRANSMITTER OF BRONCHODILATOR NERVES IN HUMANS [J].
BELVISI, MG ;
STRETTON, CD ;
YACOUB, M ;
BARNES, PJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 210 (02) :221-222
[10]   INCREASES IN ACTIVATED T-LYMPHOCYTES, EOSINOPHILS, AND CYTOKINE MESSENGER-RNA EXPRESSION FOR INTERLEUKIN-5 AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN BRONCHIAL BIOPSIES AFTER ALLERGEN INHALATION CHALLENGE IN ATOPIC ASTHMATICS [J].
BENTLEY, AM ;
MENG, Q ;
ROBINSON, DS ;
HAMID, Q ;
KAY, AB ;
DURHAM, SR .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1993, 8 (01) :35-42
12345678910