FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association

被引:12
作者
Hu, Jinsong [1 ]
Teng, Junlin [1 ]
Ding, Naizheng [1 ]
He, Mei [1 ]
Sun, Yuhui [1 ]
Yu, Albert Cheung Hoi [3 ,4 ,5 ]
Chen, Jianguo [1 ,2 ]
机构
[1] Peking Univ, Dept Cell Biol & Genet, Key Lab Cell Proliferat & Differentiat, Coll Life Sci,Minist Educ, Beijing 100871, Peoples R China
[2] Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
[3] Peking Univ, Neurosci Res Inst, Beijing 10083, Peoples R China
[4] Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 10083, Peoples R China
[5] Peking Univ, Key Lab Neurosci, Minist Educ, Minist Publ Hlth, Beijing 10083, Peoples R China
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷
关键词
D10Wsu52e gene; FAAP; cell adhesion; vinculin; paxillin; FAK;
D O I
10.2741/3215
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Focal adhesion associated protein (FAAP), encoded by murine D10Wsu52e gene, is highly homologous to human HSPC117, which interacts with vinculin and talin. HeLa cells transfected with FAAP exhibited normal adhesion incorporation but showed impaired cell spreading, and restrained focal adhesion translocation. Moreover, FAAP facilitated vinculin-paxillin association, decreased interaction of paxillin-focal adhesion kinase and inhibited the phosphorylation of extracellular signal-regulated kinase. Together, these results suggest that FAAP, by virtue of modulating interaction of adhesion molecules, regulates cell adhesion dynamics.
引用
收藏
页码:7123 / 7131
页数:9
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