Two New Cytotoxic Decalin Derivatives from Marine-Derived Fungus Talaromyces sp.

被引：9
|
作者：
Liu, Gaoran [1 ,2 ]
Huo, Ruiyun [1 ,2 ]
Niu, Shubin [3 ]
Song, Fuhang [4 ]
Liu, Ling [1 ,2 ]
机构：
[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
[3] Beijing City Univ, Sch Biol Med, Beijing 100083, Peoples R China
[4] Beijing Technol & Business Univ, Sch Light Ind, Beijing 100048, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 03期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
secondary metabolites; structural elucidation; cytotoxicity; antioxidant activity; MANGROVE ENDOPHYTIC FUNGUS; INHIBITORY-ACTIVITY; SESQUITERPENOIDS; FUSARIELINS; METABOLITES;
D O I：
10.1002/cbdv.202100990
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new decalin derivatives named fusarielins O (1) and P (2), together with seven known compounds (3-9) were isolated from the crude extract of the marine-derived fungus Talaromyces sp. The planar structures of the new compounds were elucidated by comprehensive spectroscopic analyses of NMR and HR-ESI-MS. The absolute configuration of 1 was assigned by Snatzke's method and comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1-9 were evaluated for their cytotoxic activities against three tumor cell lines and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities.
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页数：8
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