Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseases

被引：161
作者：
Ben-Ami, Eyal [1 ]
Berrih-Aknin, Sonia [2 ]
Miller, Ariel [1 ,3 ,4 ]
机构：
[1] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel
[2] UPMC, Inst Myol, UMRS 974, Paris, France
[3] Carmel Hosp, Neuroimmunol Unit, Haifa, Israel
[4] Carmel Hosp, Multiple Sclerosis Ctr, Haifa, Israel
来源：
AUTOIMMUNITY REVIEWS | 2011年 / 10卷 / 07期
关键词：
Mesenchymal stem cells; Cellular therapy; Immunomodulation; Autoimmune diseases; Multiple sclerosis; Myasthenia gravis; SUPPRESS T-LYMPHOCYTE; STROMAL CELLS; IN-VITRO; MYASTHENIA-GRAVIS; INTERFERON-GAMMA; PROGENITOR CELLS; HEALTHY DONORS; NITRIC-OXIDE; PROLIFERATION; INHIBIT;
D O I：
10.1016/j.autrev.2011.01.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent progenitor cells which can be isolated from various human adult tissues. In recent years. MSCs have been shown to possess broad immunoregulatory capabilities, modulating both adaptive and innate immunity. This review discusses the documented immunomodulatory capabilities of the MSCs, the possible mechanisms underlying these functions and presents the potential of using this stem cell-based approach as an immunomodulatory tool for the treatment of autoimmune diseases. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：410 / 415
页数：6
相关论文
共 76 条
[1]   Human mesenchymal stem cells modulate allogeneic immune cell responses [J].
Aggarwal, S ;
Pittenger, MF .
BLOOD, 2005, 105 (04) :1815-1822
[2]   Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus [J].
Al-Refu, Khitam ;
Goodfield, Mark .
AUTOIMMUNITY REVIEWS, 2009, 8 (06) :474-477
[3]   Mechanisms of T regulatory cell function [J].
Askenasy, Nadir ;
Kaminitz, Ayelet ;
Yarkoni, Shai .
AUTOIMMUNITY REVIEWS, 2008, 7 (05) :370-375
[4]   Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway [J].
Augello, A ;
Tasso, R ;
Negrini, SM ;
Amateis, A ;
Indiveri, F ;
Cancedda, R ;
Pennesi, G .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (05) :1482-1490
[5]   Intracerebroventricular Transplantation of Human Mesenchymal Stem Cells Induced to Secrete Neurotrophic Factors Attenuates Clinical Symptoms in a Mouse Model of Multiple Sclerosis [J].
Barhum, Yael ;
Gai-Castro, Sharon ;
Bahat-Stromza, Merav ;
Barzilay, Ran ;
Melamed, Eldad ;
Offen, Daniel .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2010, 41 (01) :129-137
[6]   Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].
Bartholomew, A ;
Sturgeon, C ;
Siatskas, M ;
Ferrer, K ;
McIntosh, K ;
Patil, S ;
Hardy, W ;
Devine, S ;
Ucker, D ;
Deans, R ;
Moseley, A ;
Hoffman, R .
EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48
[7]   Human mesenchymal stem cells promote survival of T cells in a quiescent state [J].
Benvenuto, Federica ;
Ferrari, Stefania ;
Gerdoni, Eno ;
Gualandi, Francesca ;
Frassoni, Francesco ;
Pistoia, Vito ;
Mancardi, Gianluigi ;
Uccelli, Antonio .
STEM CELLS, 2007, 25 (07) :1753-1760
[8]   Human bone marrow-derived mesenchymal stem cells do not undergo transformation after long-term In vitro culture and do not exhibit telomere maintenance mechanisms [J].
Bernardo, Maria Ester ;
Zaffaroni, Nadia ;
Novara, Francesca ;
Cometa, Angela Maria ;
Avanzini, Maria Antonietta ;
Moretta, Antonia ;
Montagna, Daniela ;
Maccario, Rita ;
Villa, Raffaella ;
Daidone, Maria Grazia ;
Zuffardi, Orsetta ;
Locatelli, Franco .
CANCER RESEARCH, 2007, 67 (19) :9142-9149
[9]   Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness [J].
Beyth, S ;
Borovsky, Z ;
Mevorach, D ;
Liebergall, M ;
Gazit, Z ;
Aslan, H ;
Galun, E ;
Rachmilewitz, J .
BLOOD, 2005, 105 (05) :2214-2219
[10]   Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous- and allogeneic-stimulated lymphocytes in vitro [J].
Bocelli-Tyndall, C. ;
Bracci, L. ;
Spagnoli, G. ;
Braccini, A. ;
Bouchenaki, M. ;
Ceredig, R. ;
Pistoia, V. ;
Martin, I. ;
Tyndall, A. .
RHEUMATOLOGY, 2007, 46 (03) :403-408
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