Metal-Based Aggregation-Induced Emission Theranostic Systems

被引：15

作者：

Shen, Hanchen ^{[1
]}

Xu, Changhuo ^{[1
]}

Sun, Feiyi ^{[1
]}

Zhao, Mengying ^{[1
]}

Wu, Qian ^{[1
]}

Zhang, Jianyu ^{[1
]}

Li, Sijie ^{[1
]}

Zhang, Jing ^{[2
]}

Lam, Jacky W. Y. ^{[1
]}

Tang, Ben Zhong ^{[1
,3
,4
]}

机构：

[1] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem, Hong Kong Branch,Kowloon, Clear Water Bay, Hong Kong, Peoples R China

[2] Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou 510515, Peoples R China

[3] Chinese Univ Hong Kong, Sch Sci & Engn, Shenzhen Inst Aggregate Sci & Technol, Shenzhen 518172, Peoples R China

[4] South China Univ Technol, Ctr Aggregat Induced Emiss, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China

来源：

CHEMMEDCHEM | 2022年 / 17卷 / 03期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

Aggregation-induced emission; Metal-based system; Theranostics; Photochemistry; Nanotechnology; DRUG-DELIVERY; SILVER NANOCLUSTERS; AIE; NANOPARTICLES; FLUORESCENCE; COMPLEXES; AIEGENS; EFFICACY; BEHAVIOR; ASSAY;

D O I：

10.1002/cmdc.202100578

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Efficient theranostic systems can realize better outcomes in disease treatment because of precise diagnosis and the concomitant effective therapy. Aggregation-induced emission luminogens (AIEgens) are a unique type of organic emitters with intriguing photophysical properties in the aggregate state. Among the AIEgens studied for biomedical applications, so far, metal-based AIE systems have shown great potential in theranostics due to the enhanced multimodal bioimaging ability and therapeutic effect. This research field has been growing rapidly, and many rationally designed systems with promising activities to cancer and other diseases have been reported recently. In this review, we summarized the recent progress of metal-based AIE materials in bioimaging and biological theranostics, and deciphered the pertinent design strategies. We hope that this review can offer new insights into the development of this growing field.

引用

页数：22

共 120 条

[91] Turning on Light Emission of a Dark Pro-Aggregation-Induced Emission Luminogen in Aqueous Media Through Reductase-Modulated Derotation [J].