Male infertility is a major and growing problem and, in most cases, the specific root cause is unknown. Here we show that the transcription factor SOX30 plays a critical role in mouse spermatogenesis. Sox30-null mice are healthy and females are fertile, but males are sterile. In the absence of Sox30 meiosis initiates normally in both sexes but, in males, germ cell development arrests during the post-meiotic round spermatid period. In the mutant testis, acrosome and axoneme development are aberrant, multinucleated germ cells (symplasts) form and round spermatids unable to process beyond step 3 of spermiogenesis. No elongated spermatids nor spermatozoa are produced. Thus, Sox30 represents a rare example of a gene for which loss of function results in a complete arrest of spermatogenesis at the onset of spermiogenesis. Our results suggest that SOX30 mutations may underlie some instances of unexplained non-obstructive azoospermia in humans.
引用
收藏
页数:12
相关论文
共 66 条
[1]
Ahmed EA, 2009, METHODS MOL BIOL, V558, P263, DOI 10.1007/978-1-60761-103-5_16
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Cotton, Leanne M.
Meilak, Michelle L.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Meilak, Michelle L.
Templeton, Tanya
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Templeton, Tanya
Gonzales, Jose G.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Gonzales, Jose G.
Nenci, Arianna
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Nenci, Arianna
Cooney, Melissa
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Cooney, Melissa
Truman, Dirk
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Truman, Dirk
Rodda, Fleur
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Rodda, Fleur
Lynas, Alyce
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Lynas, Alyce
Viney, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Biotechnol Ctr, Gene Targeting Lab, Bundoora, Vic 3086, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Viney, Elizabeth
Rosenthal, Nadia
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Rosenthal, Nadia
Bianco, Deborah M.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Bianco, Deborah M.
O'Bryan, Moira K.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
O'Bryan, Moira K.
Smyth, Ian M.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, Australia
Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Cotton, Leanne M.
Meilak, Michelle L.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Meilak, Michelle L.
Templeton, Tanya
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Templeton, Tanya
Gonzales, Jose G.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Gonzales, Jose G.
Nenci, Arianna
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Nenci, Arianna
Cooney, Melissa
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Cooney, Melissa
Truman, Dirk
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Truman, Dirk
Rodda, Fleur
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Rodda, Fleur
Lynas, Alyce
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Lynas, Alyce
Viney, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Biotechnol Ctr, Gene Targeting Lab, Bundoora, Vic 3086, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Viney, Elizabeth
Rosenthal, Nadia
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Rosenthal, Nadia
Bianco, Deborah M.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Bianco, Deborah M.
O'Bryan, Moira K.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
O'Bryan, Moira K.
Smyth, Ian M.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia
Monash Univ, Dept Anat & Dev Biol, Clayton, Vic 3800, Australia
Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, AustraliaMonash Univ, APN, Embryon Stem Cell ES Cell To Mouse Serv, Clayton, Vic 3800, Australia