Decrease in Incidence of Young-Onset Colorectal Cancer Before Recent Increase

被引：85
作者：
Murphy, Caitlin C. [1 ,2 ,3 ,4 ]
Singal, Amit G. [1 ,2 ,3 ,4 ]
Baron, John A. [1 ,2 ,3 ,4 ]
Sandler, Robert S. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA
[3] Harold C Simmons Comprehens Canc Ctr, Dallas, TX USA
[4] Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27515 USA
来源：
GASTROENTEROLOGY | 2018年 / 155卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Colorectal Neoplasia; Incidence; Young Adult; Birth Cohort; UNITED-STATES; RISK; ANTIBIOTICS; AGE; COLON;
D O I：
10.1053/j.gastro.2018.07.045
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The increasing incidence of colorectal cancer in younger adults (aged <50 years) has been widely reported. Using data from the Surveillance, Epidemiology, and End Results Program, we found young-onset colorectal cancer incidence rates decreased from 1975 through about 1990. Decreases were more prominent in the colon, a contrast with more recent increases in rectal cancer. Incidence rates subsequently increased, differing by time period and 5-year age group. This inflection point is consistent with a birth cohort effect and points to early life exposures-accumulated throughout the life course-that may increase cancer risk. Studying early life exposures among persons born after 1960 may advance our understanding of colorectal cancer in younger adults.
引用
收藏
页码：1716 / +
页数：8
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