Two-Component Systems and Their Co-Option for Eukaryotic Signal Transduction

被引:163
作者
Schaller, G. Eric [1 ]
Shiu, Shin-Han [2 ]
Armitage, Judith P. [3 ]
机构
[1] Dartmouth Coll, Dept Biol Sci, Hanover, NH 03755 USA
[2] Michigan State Univ, Dept Plant Biol, E Lansing, MI 48824 USA
[3] Univ Oxford, Dept Biochem, Oxford Ctr Integrat Syst Biol, Oxford OX1 3QU, England
基金
英国生物技术与生命科学研究理事会;
关键词
HISTIDINE PHOSPHOTRANSFER PROTEINS; B RESPONSE REGULATORS; ETR1 ETHYLENE RECEPTOR; WHOLE-GENOME ANALYSIS; CIRCADIAN CLOCK; CYTOKININ RECEPTOR; PHYTOCHROME FPHA; LIGAND-BINDING; KINASE CASCADE; LIFE-CYCLE;
D O I
10.1016/j.cub.2011.02.045
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two-component signaling pathways involve histidine kinases, response regulators, and sometimes histidine-containing phosphotransfer proteins. Prevalent in prokaryotes, these signaling elements have also been co-opted to meet the needs of signal transduction in eukaryotes such as fungi and plants. Here we consider the evolution of such regulatory systems, with a particular emphasis on the roles they play in signaling by the plant hormones cytokinin and ethylene, in phytochrome-mediated perception of light, and as integral components of the circadian clock.
引用
收藏
页码:R320 / R330
页数:11
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