Modeling Neurological Diseases With Human Brain Organoids

被引：123
|
作者：
Wang, Hansen [1 ]
机构：
[1] Univ Toronto, Fac Med, Toronto, ON, Canada
来源：
FRONTIERS IN SYNAPTIC NEUROSCIENCE | 2018年 / 10卷
关键词：
brain organoids; pluripotent stem cells; neurological diseases; neurodevelopmental disorders; neurodegenerative diseases; iPSCs; autism; Alzheimer disease; PLURIPOTENT STEM-CELLS; AUTISM SPECTRUM DISORDERS; ZIKA-VIRUS; CEREBRAL ORGANOIDS; CORTICAL DEVELOPMENT; SELF-ORGANIZATION; NEURAL PROGENITORS; MINI-BRAINS; MUTATIONS; DIFFERENTIATION;
D O I：
10.3389/fnsyn.2018.00015
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The complexity and delicacy of human brain make it challenging to recapitulate its development, function and disorders. Brain organoids derived from human pluripotent stem cells (PSCs) provide a new tool to model both normal and pathological human brain, and greatly enhance our ability to study brain biology and diseases. Currently, human brain organoids are increasingly used in modeling neurological disorders and relative therapeutic discovery. This review article focuses on recent advances in human brain organoid system and its application in disease modeling. It also discusses the limitations and future perspective of human brain organoids in modeling neurological diseases.
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页数：14
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