The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism

被引:554
作者
Tatemoto, K [1 ]
Takayama, K
Zou, MX
Kumaki, I
Zhang, W
Kumano, K
Fujimiya, M
机构
[1] Gunma Univ, Inst Mol & Cellular Regulat, Dept Mol Physiol, Maebashi, Gumma 3718512, Japan
[2] Gunma Univ, Sch Hlth Sci, Dept Lab Sci, Maebashi, Gumma 3718514, Japan
[3] Shiga Univ Med Sci, Dept Anat, Otsu, Shiga 5202192, Japan
关键词
apelin; APJ; blood pressure; nitric oxide; endothelial NO synthase;
D O I
10.1016/S0167-0115(01)00236-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Apelin is an endogenous ligand of the human orphan receptor APJ. We detected apelin-like immunoreactivity in the adipocytes, gastric mucosa, and Kupffer cells in the liver. We also detected apelin-like immunoreactivity localized within the endothelia of small arteries in various organs. Further, it was found that mean arterial pressure after the administration of apelin-12, apelin-13, and apelin-36 at a dose of 10 nmol/kg in anaesthetized rats was reduced by 26 +/- 5, 11 +/- 4, and 5 +/- 4 mm Hg, respectively. In the presence of a nitric oxide (NO) synthase inhibitor, the effect of apelin-12 on blood pressure was abolished. Furthermore, the administration of apelin-12. (10 nmol/kg) in rats produced a transitory elevation of the plasma nitrite/nitrate concentration from a basal level of 21.4 +/- 1.6 to 27.0 +/- 1.5 muM Thus, apelin may lower blood pressure via a nitric oxide-dependent mechanism. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:87 / 92
页数:6
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