Response of renal nerve activity to high NaCl food intake in dogs with chronic bile duct ligation

被引:0
作者
Matsuda, T [1 ]
Morita, H [1 ]
Hosomi, H [1 ]
Okada, M [1 ]
机构
[1] KOBE UNIV,SCH MED,DEPT SURG 2,HYOGO,JAPAN
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R57 [消化系及腹部疾病];
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摘要
Hepatic sensory systems are thought to play an important role in the response of renal nerve activity and natriuresis to oral NaCl load, In this study, responses of renal nerve activity and urinary Na+ and Cl- excretions to a high-NaCl food intake (20 g/kg boiled rice containing 0.4 g/kg NaCl) were examined in sham-operated dogs (n = 12) and dogs with chronic bile duct ligation (CBDL; n = 10). In sham-operated dogs, renal nerve activity gradually decreased and reached minimal value (50% +/- 7% of the control value) at 100 minutes after the high-NaCl food intake and remained depressed until 4 hours after the food intake. Of the orally administered sodium and chloride, 27% +/- 5% and 23% +/- 6% were excreted over the following 4 hours, respectively, In CBDL dogs, the decrease in renal nerve activity induced by the high-NaCl food was completely abolished and only 4% +/- 1% of the loaded Na+ and 3% +/- 2% of the loaded Cl- were excreted, Furthermore, liver tissue norepinephrine concentration in CBDL dogs decreased to 21% of that of sham-operated dogs, These results suggest that (1) In CBDL dogs, the decrease in renal nerve activity induced by a high-NaCl food is completely abolished, probably because of the impairment of hepatic neural regulation, (2) The lack of renal nerve response may contribute, at least in part, to the abnormalities in body fluid homeostasis in cirrhosis.
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页码:303 / 309
页数:7
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共 41 条
  • [1] HEPATIC OSMORECEPTOR MECHANISM IN RAT - ELECTROPHYSIOLOGICAL AND BEHAVIORAL-STUDIES
    ADACHI, A
    NIIJIMA, A
    JACOBS, HL
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1976, 231 (04): : 1043 - 1049
  • [2] EFFECT OF OSMOTIC-PRESSURE ON SPONTANEOUS AFFERENT DISCHARGE IN NERVES OF PERFUSED RABBIT LIVER
    ANDREWS, WHH
    ORBACH, J
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1975, 361 (01): : 89 - 94
  • [3] SODIUM RECEPTORS ACTIVATING SOME NERVES OF PERFUSED RABBIT LIVERS
    ANDREWS, WHH
    ORBACH, J
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1974, 227 (06): : 1273 - 1275
  • [4] EFFECT OF ORAL PROPRANOLOL ADMINISTRATION ON AZYGOS, RENAL AND HEPATIC-UPTAKE AND OUTPUT OF CATECHOLAMINES IN CIRRHOSIS
    BENDTSEN, F
    CHRISTENSEN, NJ
    SORENSEN, TIA
    HENRIKSEN, JH
    [J]. HEPATOLOGY, 1991, 14 (02) : 237 - 243
  • [5] EFFECT OF CHRONIC BILE-DUCT OBSTRUCTION ON RENAL HANDLING OF SALT AND WATER
    BETTER, OS
    MASSRY, SG
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1972, 51 (02) : 402 - &
  • [6] BOSCH J, 1983, HEPATOLOGY, V3, P1002
  • [7] CASTLEMAN L, 1958, J LAB CLIN MED, V51, P897
  • [8] EVALUATION OF SELECTIVE LIVER DENERVATION METHODS
    CUCCHIARO, G
    YAMAGUCHI, Y
    MILLS, E
    KUHN, CM
    ANTHONY, DC
    BRANUM, GD
    EPSTEIN, R
    MEYERS, WC
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (05): : G781 - G785
  • [9] DALY JJ, 1967, CLIN SCI, V33, P481
  • [10] ROLE OF RENAL NERVES IN SODIUM RETENTION OF CIRRHOSIS AND CONGESTIVE-HEART-FAILURE
    DIBONA, GF
    SAWIN, LL
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (02): : R298 - R305