Neutrophil CD64 as a Diagnostic Marker of Sepsis: Impact on Neonatal Care

被引：15
|
作者：
Lynema, Stephanie [1 ]
Marmer, Daniel [2 ]
Hall, Eric S. [1 ]
Meinzen-Derr, Jareen [3 ]
Kingma, Paul S. [1 ,4 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Sect Neonatol Perinatal & Pulm Biol, Perinatal Inst, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst Lab, Cincinnati, OH 45229 USA
[3] Cincinnati Childrens Hosp Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA
[4] Cincinnati Childrens Hosp Med Ctr, Cincinnati Fetal Ctr, Cincinnati, OH 45229 USA
来源：
AMERICAN JOURNAL OF PERINATOLOGY | 2015年 / 32卷 / 04期
基金：
美国国家卫生研究院;
关键词：
CD64; neonatal infection; sepsis; sepsis marker; C-REACTIVE PROTEIN; BIRTH-WEIGHT INFANTS; BLOOD-CELL COUNT; RESEARCH NETWORK; LEUKOCYTE INDEXES; ONSET SEPSIS; PROCALCITONIN; INFECTION; EXPRESSION; CHILDREN;
D O I：
10.1055/s-0034-1384644
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
ObjectiveThe aim of this study is to determine the validity and reliability of neutrophil CD64 in identifying infected infants and to evaluate the impact of this marker on clinical care. Study DesignNeutrophil CD64 index was incorporated in 371 infection evaluations in 234 infants (ages 1-293 days) from 2005 to 2009 and the impact of this change on clinical care was evaluated. ResultsThe sensitivity of the neutrophil CD64 assay was 87% in identifying 31 episodes of culture positive sepsis and 83% in identifying 12 infants with ventilator-associated pneumonia. There was no difference in the mean number of antibiotic days in infants with a normal CD64 versus those with a normal complete blood count (CBC) (p=0.89), but twofold more infants were identified as not infected by CD64 than by CBC. ConclusionCD64 had a high sensitivity for identifying infected infants while also decreasing the number of infants that were exposed to unnecessary antibiotic use.
引用
收藏
页码：331 / 336
页数：6
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