Modular C-H Functionalization Cascade of Aryl Iodides

被引：155

作者：

Shi, Hang ^{[1
]}

Babinski, David J. ^{[1
]}

Ritter, Tobias ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 11期

基金：

美国国家科学基金会;

关键词：

TOSYLHYDRAZONE INSERTION REACTION; U-SHAPED TEMPLATE; PALLADIUM(II) COMPLEX; NORBORNENE; VINYLARENES; ACTIVATION; PD; HALIDES; HETEROCYCLES; OLEFINATION;

D O I：

10.1021/jacs.5b01082

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first example of ipsoborylation for the modular 1,2-bisfunctionalization of aryl iodides via C-H functionalization. The carbon-boron bond is used as a lynchpin to access ipso carbon-carbon, carbon-nitrogen, carbon oxygen, and carbon-halogen (Cl, Br, I) bonds. The utility of our methodology is illustrated through quick, modular syntheses of the pharmaceuticals Abilify and Flunixin.

引用

页码：3775 / 3778

页数：4

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