Glucocorticoid treatment of ovariectomized sheep affects mineral density, structure, and mechanical properties of cancellous bone

被引：46

作者：

Schorlemmer, S ^{[1
]}

Gohl, C ^{[1
]}

Iwabu, S ^{[1
]}

Ignatius, A ^{[1
]}

Claes, L ^{[1
]}

Augat, P ^{[1
]}

机构：

[1] Univ Ulm, Inst Orthopaed Res & Biomech, Ulm, Germany

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2003年 / 18卷 / 11期

关键词：

osteoporosis; corticosteroids; biomechanics; bone histomorphometry; bone quantitative computed tomography;

D O I：

10.1359/jbmr.2003.18.11.2010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thus far, orthopedic research lacks a suitable animal model of osteoporosis. In OVX sheep, 6 months of steroid exposure reduced bone density and mechanical competence. Bone properties and bone formation did not recover for another 6 months. Therefore, steroid-treated OVX sheep may serve as a large animal model for osteopenic bone.

引用

页码：2010 / 2015

页数：6

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