Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

被引：216

作者：

Fugger, Lars ^{[1
,2
,3
]}

Jensen, Lise Torp ^{[1
,3
]}

Rossjohn, Jamie ^{[4
,5
,6
,7
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Div Clin Neurol, Nuffield Dept Clin Neurosci,Oxford Ctr Neuroinfla, Oxford OX3 9DS, England

[2] Univ Oxford, Weatherall Inst Mol Med, John Radcliffe Hosp, MRC Human Immunol Unit, Oxford OX3 9DS, England

[3] Aarhus Univ Hosp, Dept Clin Med, DK-8200 Aarhus N, Denmark

[4] Monash Univ, Infect & Immun Program, Biomed Discovery Inst, Clayton, Vic 3800, Australia

[5] Monash Univ, Dept Biochem & Mol Biol, Biomed Discovery Inst, Clayton, Vic 3800, Australia

[6] Monash Univ, Australian Res Council Ctr Excellence Adv Mol Ima, Clayton, Vic 3800, Australia

[7] Cardiff Univ, Sch Med, Inst Infect & Immun, Heath Pk, Cardiff CF14 4XN, Wales

来源：

CELL | 2020年 / 181卷 / 01期

基金：

澳大利亚研究理事会; 英国惠康基金;

关键词：

INFLAMMATORY-BOWEL-DISEASE; REGULATORY B-CELLS; ANTI-TNF THERAPY; T-CELLS; CROSS-REACTIVITY; TARGETED THERAPY; GUT MICROBIOTA; GENETIC RISK; DOUBLE-BLIND; METABOLITES;

D O I：

10.1016/j.cell.2020.03.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.

引用

页码：63 / 80

页数：18

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