The 2-chlorotrityl resin: a worthy addition to the medicinal chemist's toolbox

被引：11
|
作者：
Hoekstra, WJ [1 ]
机构：
[1] GlaxoSmithKline, Discovery Res Chem, Res Triangle Pk, NC 27709 USA
来源：
CURRENT MEDICINAL CHEMISTRY | 2001年 / 8卷 / 06期
关键词：
D O I：
10.2174/0929867013373192
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The polystyrene-based 2-chlorotrityl resin was originally used in the synthesis of peptides using an Fmoc-amino acid/carboxyl-linked protocol. While traditionally employed to prepare a number of biologically active peptides, the resin has received increasing attention as a support for the synthesis of pseudopeptide and non-peptide molecules recently. This review focuses on 2-chlorotrityl resin-supported synthesis of small molecules that collectively display a broad range of biological activities.
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收藏
页码：715 / 719
页数：5
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