Synthesis and photophysical properties of a fluorescent TREN-type ligand incorporating the coumarin chromophore and its zinc complex

被引：20
作者：
Dakanali, M
Roussakis, E
Kay, AR
Katerinopoulos, HE [1 ]
机构：
[1] Univ Crete, Dept Chem, Div Organ Chem, Iraklion 71409, Crete, Greece
[2] Univ Iowa, Dept Biol Sci, Iowa City, IA 52242 USA
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 24期
关键词：
D O I：
10.1016/j.tetlet.2005.04.059
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new, UV-excited fluorescent Zn2+ indicator was synthesized and the spectral profile of its free and Zn2+ bound forms were studied. The fluorescent properties of this probe are due to the 7-amino-4-methylcoumarin fluorophore, which is conjugated with the tris(2-aminoethyl)amine (TREN) that functions as the zinc-chelating moiety. The compound exhibits a Zn2+ dissociation constant of 18.0 mu M. The fluorescence spectra of the probe showed a clear shift in excitation wavelength maxima upon Zn2+ binding, indicating its potential use as ratiometric Zn2+ indicator. (c) 2005 Elsevier Ltd. All rights reserved.
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页码：4193 / 4196
页数：4
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