DNA binding and photocleavage properties of two mixed-ligand oxovanadium complexes

被引：27

作者：

Du, Yi-fan ^{[1
]}

Lu, Jia-Zheng ^{[1
]}

Guo, Hai-wei ^{[1
]}

Jiang, Jing ^{[1
]}

Chao, Ping ^{[1
]}

Chen, Fei ^{[1
]}

Pan, Jie-Ming ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Dept Chem, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China

来源：

TRANSITION METAL CHEMISTRY | 2010年 / 35卷 / 07期

关键词：

VANADIUM COMPLEXES; CRYSTAL-STRUCTURE; IN-VITRO; THIOSEMICARBAZONES; CLEAVAGE;

D O I：

10.1007/s11243-010-9404-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An oxovanadium complex [VO(satsc)(bipy)] (1) (satsc = salicylaldehyde thiosemicarbazone, bipy = 2,2 '-bipyridine) and its dibromo derivative [VO(3,5-dibrsatsc)(bipy)] (2) (3,5-dibrsatsc = 3,5-dibromosalicylalde-hyde thiosemicarbazone) have been synthesized and characterized by elemental analysis, IR, ES-MS and 1 H NMR. The interaction of these two complexes with calf-thymus DNA (CT-DNA) was studied using UV/Vis, fluorescence spectroscopic titration, viscosity measurements and thermal denaturation. The results suggest that complexes 1 and 2 interact with CT-DNA by intercalative modes. The DNA-binding affinity of complex 1 is larger than that of complex 2. In addition, their photocleavage reactions with pBR322 supercoiled plasmid DNA were investigated by gel electrophoresis experiments. Both complexes exhibit significant DNA cleavage activity, and complex 1 showed greater cleaving efficiency than complex 2.

引用

页码：859 / 864

页数：6

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