Review Article Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability

被引：179

作者：

Carita, Amanda Costa ^{[1
]}

Fonseca-Santos, Bruno ^{[2
]}

Shultz, Jemima Daniela ^{[1
,2
,3
]}

Michniak-Kohn, Bozena ^{[3
]}

Chorilli, Marlus ^{[2
]}

Leonardi, Gislaine Ricci ^{[4
]}

机构：

[1] Univ Fed Sao Paulo, Dept Translat Med, Sao Paulo, Brazil

[2] Sao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara, SP, Brazil

[3] Rutgers State Univ, Dept Pharmaceut, Ernest Mario Sch Pharm, Piscataway, NJ USA

[4] Univ Estadual Campinas, Coll Pharmaceut Sci, Campinas, Brazil

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2020年 / 24卷

基金：

巴西圣保罗研究基金会;

关键词：

Ascorbic acid; Drug delivery; Nanoparticles; Liposomes; Microemulsions; Targeting; MESOPOROUS SILICA NANOPARTICLES; L-ASCORBIC-ACID; DEPENDENT DNA DEMETHYLATION; PALMITOYL ASCORBATE; DRUG-DELIVERY; LIPOSOMES; SKIN; CELLS; PHOTOPROTECTION; ENCAPSULATION;

D O I：

10.1016/j.nano.2019.102117

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Vitamin C (Vit C) is a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. However, the biggest challenge in the utilization of Vit C is to maintain its stability and improve its delivery to the active site. Several strategies have been developed such as: controlling the oxygen levels during formulation and storage, low pH, reduction of water content in the formulation and the addition of preservative agents. Additionally, the utilization of derivatives of Vit C and the development of micro and nanoencapsulated delivery systems have been highlighted. In this article, the multiple applications and mechanisms of action of vitamin C will be reviewed and discussed, as well as the new possibilities of delivery and improvement of stability. (C) 2019 The Author(s). Published by Elsevier Inc.

引用

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