Review Article Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability

被引：177

作者：

Carita, Amanda Costa ^{[1
]}

Fonseca-Santos, Bruno ^{[2
]}

Shultz, Jemima Daniela ^{[1
,2
,3
]}

Michniak-Kohn, Bozena ^{[3
]}

Chorilli, Marlus ^{[2
]}

Leonardi, Gislaine Ricci ^{[4
]}

机构：

[1] Univ Fed Sao Paulo, Dept Translat Med, Sao Paulo, Brazil

[2] Sao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara, SP, Brazil

[3] Rutgers State Univ, Dept Pharmaceut, Ernest Mario Sch Pharm, Piscataway, NJ USA

[4] Univ Estadual Campinas, Coll Pharmaceut Sci, Campinas, Brazil

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2020年 / 24卷

基金：

巴西圣保罗研究基金会;

关键词：

Ascorbic acid; Drug delivery; Nanoparticles; Liposomes; Microemulsions; Targeting; MESOPOROUS SILICA NANOPARTICLES; L-ASCORBIC-ACID; DEPENDENT DNA DEMETHYLATION; PALMITOYL ASCORBATE; DRUG-DELIVERY; LIPOSOMES; SKIN; CELLS; PHOTOPROTECTION; ENCAPSULATION;

D O I：

10.1016/j.nano.2019.102117

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Vitamin C (Vit C) is a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. However, the biggest challenge in the utilization of Vit C is to maintain its stability and improve its delivery to the active site. Several strategies have been developed such as: controlling the oxygen levels during formulation and storage, low pH, reduction of water content in the formulation and the addition of preservative agents. Additionally, the utilization of derivatives of Vit C and the development of micro and nanoencapsulated delivery systems have been highlighted. In this article, the multiple applications and mechanisms of action of vitamin C will be reviewed and discussed, as well as the new possibilities of delivery and improvement of stability. (C) 2019 The Author(s). Published by Elsevier Inc.

引用

页数：15

共 85 条

[1] Photostability and Interaction of Ascorbic Acid in Cream Formulations [J].

Ahmad, Iqbal ;

Sheraz, Muhammad Ali ;

Ahmed, Sofia ;

Shaikh, Riaz Hussain ;

Vaid, Faiyaz H. M. ;

Khattak, Saif Ur Rehman ;

Ansari, Shakeel A. .

AAPS PHARMSCITECH, 2011, 12 (03) :917-923

[2] Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery [J].

Ahmed, Tarek A. ;

Aljaeid, Bader M. .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 10 :483-507

[3] Shelf life and delivery enhancement of vitamin C using chitosan nanoparticles [J].

Alishahi, A. ;

Mirvaghefi, A. ;

Tehrani, M. R. ;

Farahmand, H. ;

Shojaosadati, S. A. ;

Dorkoosh, F. A. ;

Elsabee, Maher Z. .

FOOD CHEMISTRY, 2011, 126 (03) :935-940

[4]

Anderson PM, 2008, Patent number US, Patent No. [US 9,445,975 B2, 9445975]

[5] LIPOSOME ELECTROFORMATION [J].

ANGELOVA, MI ;

DIMITROV, DS .

FARADAY DISCUSSIONS, 1986, 81 :303-+

[6]

[Anonymous], 2018, MARCES BOOK SER

[7] What is a clinical trial? [J].

Aronson, JK .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2004, 58 (01) :1-3

[8] SYNERGISTIC KILLING OF EHRLICH ASCITES CARCINOMA CELLS BY ASCORBATE AND 3-AMINO-1,2,4-TRIAZOLE [J].

BENADE, L ;

HOWARD, T ;

BURK, D .

ONCOLOGY, 1969, 23 (01) :33-&

[9] Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells [J].

Blaschke, Kathryn ;

Ebata, Kevin T. ;

Karimi, Mohammad M. ;

Zepeda-Martinez, Jorge A. ;

Goyal, Preeti ;

Mahapatra, Sahasransu ;

Tam, Angela ;

Laird, Diana J. ;

Hirst, Martin ;

Rao, Anjana ;

Lorincz, Matthew C. ;

Ramalho-Santos, Miguel .

NATURE, 2013, 500 (7461) :222-+

[10] LIPOSOME PREPARATION BY A NEW HIGH-PRESSURE HOMOGENIZER GAULIN MICRON LAB-40 [J].

BRANDL, M ;

BACHMANN, D ;

DRECHSLER, M ;

BAUER, KH .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1990, 16 (14) :2167-2191

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