Enantioselective liquid-liquid extraction of valine enantiomers in the aqueous two-phase system formed by the cholinium amino acid ionic updates liquid copper complexes and salt

被引:25
作者
Liu, Lianglei [1 ]
Sun, Danyu [1 ]
Li, Fenfang [1 ]
Ma, Shaoping [1 ]
Tan, Zhijian [2 ,3 ]
机构
[1] Cent S Univ, Coll Chem & Chem Engn, Changsha, Peoples R China
[2] Chinese Acad Agr Sci, Inst Bast Fiber Crops, Changsha 410205, Peoples R China
[3] Chinese Acad Agr Sci, Ctr Southern Econ Crops, Changsha 410205, Peoples R China
基金
中国国家自然科学基金;
关键词
Aqueous two-phase system; Cholinium amino acid ionic liquids; Copper complexes; Valine enantiomers; Enantioseparation; OCTANOL/WATER PARTITION-COEFFICIENTS; CHIRAL SEPARATION; OUT EXTRACTION; MANDELIC-ACID; ANTHRAQUINONES; TOXICITY; SULFATE; ENANTIOSEPARATION; CHROMATOGRAPHY; CYTOTOXICITY;
D O I
10.1016/j.molliq.2019.111599
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
It was widely reported that the heterocyclic ionic liquids (ILs) had relatively high biotoxicity and the cholinium amino acid ionic liquids (ChAAILs) were much environmentally friendly. Therefore, the ChAAILs/salt aqueous two-phase systems (ATPS5) were developed for the chiral resolution of valine enantiomers in this study. The copper complexes were prepared by ChAAILs and Cu(Ac)(2), which can be used as both the phase-forming components and the chiral selectors. A series of factors affecting the enantioseparation result were investigated, including type and concentration of ChAAILs, molar ratio of ChAAIL and Cu(Ac)(2), type and concentration of salt, concentration of valine, and operation temperature. The valine enantiomers were preferentially recognized in the ChAAIL-rich phase (top phase) and the maximum e.e. value of 55.6% was obtained in the top phase. This ATPS used for the enantioseparation of valine enantiomers has the advantages of environmental friendliness, high enantioseparation efficiency and simple operation by one step extraction. (C) 2019 Elsevier B.V. All rights reserved.
引用
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页数:7
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