Successful osimertinib treatment for leptomeningeal carcinomatosis from lung adenocarcinoma with the T790M mutation of EGFR

被引：9

作者：

Sakai, Hitomi ^{[1
]}

Hayashi, Hidetoshi ^{[1
]}

Iwasa, Tsutomu ^{[1
]}

Hasegawa, Yoshikazu ^{[2
]}

Takeda, Masayuki ^{[1
]}

Nakagawa, Kazuhiko ^{[1
]}

机构：

[1] Kindai Univ Fac Med, Dept Med Oncol, Osaka, Japan

[2] Izumi Municipal Hosp, Dept Med Oncol, Izumi, Japan

来源：

ESMO OPEN | 2017年 / 2卷

关键词：

ACQUIRED-RESISTANCE; CANCER; GEFITINIB; ERLOTINIB; METASTASES; EFFICACY; AZD9291; BRAIN;

D O I：

10.1136/esmoopen-2016-000104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) that has been approved for the treatment of metastatic non-small cell lung cancer (NSCLC) positive for the secondary T790M mutation of EGFR. In a preclinical study, it also showed efficacy against leptomeningeal carcinomatosis (LMC) derived from NSCLC resistant to first-generation and second-generation EGFR-TKIs. We now report the case of a patient aged 70 years with symptomatic LMC derived from NSCLC with the T790M mutation of EGFR who showed a clinical and radiographic response to osimertinib.

引用

页数：3

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