Epigenetic Matters: The Link between Early Nutrition, Microbiome, And Long-term Health Development

被引:134
作者
Indrio, Flavia [1 ]
Martini, Silvia [2 ]
Francavilla, Ruggiero [1 ]
Corvaglia, Luigi [2 ]
Cristofori, Fernanda [1 ]
Mastrolia, Salvatore Andrea [3 ]
Neu, Josef [4 ]
Rautava, Samuli [5 ]
Spena, Giovanna Russo [6 ]
Raimondi, Francesco [6 ]
Loverro, Giuseppe [3 ]
机构
[1] Aldo Moro Univ, Dept Pediat, Bari, Italy
[2] Univ Bologna, St Orsola Malpighi Hosp, Dept Med & Surg Sci, Neonatol & Neonatal Intens Care Unit, Bologna, Italy
[3] Aldo Moro Univ, Dept Biomed Sci & Human Oncol, Sect Obstet & Gynecol, Bari, Italy
[4] Univ Florida, Dept Pediat, Div Neonatol, Gainesville, FL USA
[5] Univ Turku, Turku Univ Hosp, Dept Pediat, Turku, Finland
[6] Univ Federico II Napoli, Dept Translat Med Sci, Div Neonatol, Naples, Italy
来源
FRONTIERS IN PEDIATRICS | 2017年 / 5卷
关键词
epigenetic regulation; fetal programming; overnutrition; undernutrition; micronutrients; human milk; microbiome; disease origin; HIGH-FAT DIET; IRRITABLE-BOWEL-SYNDROME; MESSENGER-RNA EXPRESSION; ACTIVATED-RECEPTOR-GAMMA; VITAMIN-D STATUS; GUT MICROBIOTA; DNA METHYLATION; INFLAMMATORY RESPONSE; BRAIN-DEVELOPMENT; IN-UTERO;
D O I
10.3389/fped.2017.00178
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Epigenetic modifications are among the most important mechanisms by which environmental factors can influence early cellular differentiation and create new phenotypic traits during pregnancy and within the neonatal period without altering the deoxyribonucleic acid sequence. A number of antenatal and postnatal factors, such as maternal and neonatal nutrition, pollutant exposure, and the composition of microbiota, contribute to the establishment of epigenetic changes that can not only modulate the individual adaptation to the environment but also have an influence on lifelong health and disease by modifying inflammatory molecular pathways and the immune response. Postnatal intestinal colonization, in turn determined by maternal flora, mode of delivery, early skin-to-skin contact and neonatal diet, leads to specific epigenetic signatures that can affect the barrier properties of gut mucosa and their protective role against later insults, thus potentially predisposing to the development of late-onset inflammatory diseases. The aim of this review is to outline the epigenetic mechanisms of programming and development acting within early-life stages and to examine in detail the role of maternal and neonatal nutrition, microbiota composition, and other environmental factors in determining epigenetic changes and their short-and long-term effects.
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页数:14
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