Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor necrosis factor-α in rats

被引：17
作者：
Azab, A [1 ]
Fraifeld, V [1 ]
Kaplanski, J [1 ]
机构：
[1] Ben Gurion Univ Negev, Dept Clin Pharmacol, IL-84105 Beer Sheva, Israel
来源：
LIFE SCIENCES | 1998年 / 63卷 / 23期
关键词：
nimesulide; TNF-alpha; lipopolysaccharide; rat;
D O I：
10.1016/S0024-3205(99)80011-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The present study was undertaken to test the hypothesis of possible inhibitory effect of nimesulide (4-nitro-2-phenoxymethane-sulfoxide) on plasma TNF-alpha level. Male Sprague-Dawley rats were injected intraperitoneally (ip) with E. coli Lipopolysaccharide (LBS; 1 mg/kg), which resulted in a dramatic increase in plasma TNF-alpha level peaked 60 min post injection (3890 +/- 280 pg/ml, compared to undetectable values in the control group). Nimesulide (30 mg/kg) injected ip 60 min prior to LPS, prevented LPS-induced elevation in plasma TNF-alpha. Nimesulide alone did not alter circulating levels of TNF-alpha. It appears that the anti-inflammatory properties of nimesulide may in part be attributed to its inhibitory effect on TNF-alpha production. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：PL323 / PL327
页数：5
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