Catalytic cyclopropanation of methylenecyclobutanes using ethyl nitrodiazoacetate. Synthesis of spirohexane amino acids

被引：24

作者：

Yashin, NV ^{[1
]}

Averina, EB ^{[1
]}

Gerdov, SM ^{[1
]}

Kuznetsova, TS ^{[1
]}

Zefirov, NS ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119899, Russia

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 45期

关键词：

ethyl nitrodiazoacetate; spirohexane amino acids; 1+2]cycloaddition; 2+3]-cycloaddition; 1-ethoxycarbonyl-nitropolyspirocycloalkanes;

D O I：

10.1016/j.tetlet.2003.09.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of ethyl nitrodiazoacetate with a series of methylenecyclobutanes was studied and both [1+2]- and [2+3]-cycloaddition pathways were observed depending on olefin structure. Amino acids of a spirohexane type were synthesized from methylenecyclobutanes by a three-step synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8241 / 8244

页数：4