Surveillance trends of carbapenem-resistant Enterobacteriaceae from Singapore, 2010-2013

被引：15

作者：

Teo, Jeanette W. P. ^{[1
]}

Tan, Paul ^{[2
]}

La, My-Van ^{[2
]}

Krishnan, Prabha ^{[3
]}

Tee, Nancy ^{[4
]}

Koh, Tse Hsien ^{[5
]}

Deepak, Rama Narayana ^{[6
]}

Tan, Thean Yen ^{[7
]}

Jureen, Roland ^{[1
]}

Lin, Raymond T. P. ^{[1
,2
]}

机构：

[1] Natl Univ Hlth Syst, Singapore 119074, Singapore

[2] Natl Publ Hlth Lab, Minist Hlth, Singapore, Singapore

[3] Tan Tack Seng Hosp, Singapore 308433, Singapore

[4] KK Womens & Childrens Hosp, Singapore 229899, Singapore

[5] Singapore Gen Hosp, Singapore 169856, Singapore

[6] Khoo Teck Puat Hosp, Singapore 768828, Singapore

[7] Changi Gen Hosp, Singapore 529889, Singapore

来源：

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | 2014年 / 2卷 / 02期

关键词：

Carbapenemase; Antibiotic resistance; Plasmid; Clonality; KLEBSIELLA-PNEUMONIAE; NDM-TYPE; EMERGENCE; EPIDEMIOLOGY; STRAINS; PLASMID;

D O I：

10.1016/j.jgar.2013.11.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Trends in carbapenem-resistant Enterobacteriaceae (CRE) collected from hospitals nationwide in Singapore over 3 years are presented. Hospital isolates with imipenem or meropenem minimum inhibitory concentrations (MICs) of >1 mg/L were sent to the National Public Health Laboratory for further investigation. A total of 400 CRE were submitted, 227 (56.8%) of which carried a carbapenemase gene. bla(NDM) was the most common (130/400; 32.5%), followed by bla(OXA-48-like) (bla(OXA-48, -181, -232)) (55/ 400; 13.8%). Interestingly, four isolates bearing dual carbapenemase genes were also detected. KPC- and OXA-48-like-producing Klebsiella pneumoniae were fingerprinted by DiversiLabo (R) rep-PCR. Locally, KPC producers do not appear to have clonal dissemination. In contrast, OXA-48-like producers were found to have a greater degree of clustering than KPC producers. (c) 2013 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

引用

页码：99 / 102

页数：4

共 15 条

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