Increased Oral Bioavailability of Itraconazole and Its Active Metabolite, 7-Hydroxyitraconazole, When Coadministered With a Vitamin C Beverage in Healthy Participants

被引：29

作者：

Bae, Soo Kyung ^{[1
,2
,3
,4
]}

Park, Soo-Jin ^{[1
,2
]}

Shim, Eon-Jeong ^{[1
,2
]}

Mun, Ji-Hyun ^{[1
,2
]}

Kim, Eun-Young ^{[3
,4
]}

Shin, Jae-Gook ^{[1
,2
,3
,4
]}

Shon, Ji-Hong ^{[1
,2
,3
,4
]}

机构：

[1] Inje Univ, Coll Med, Dept Pharmacol, Pusan 614735, South Korea

[2] Inje Univ, Coll Med, PharmacoGenom Res Ctr, Pusan 614735, South Korea

[3] Inje Univ, Busan Paik Hosp, Dept Clin Pharmacol, Pusan, South Korea

[4] Inje Univ, Busan Paik Hosp, Clin Trial Ctr, Pusan, South Korea

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 2011年 / 51卷 / 03期

关键词：

vitamin C beverage; itraconazole; 7-hydroxyitraconazole; absorption; cola; P-GLYCOPROTEIN; GASTRIC-ACIDITY; COCA-COLA; PHARMACOKINETICS; ABSORPTION; KETOCONAZOLE; CAFFEINE; FOOD; VOLUNTEERS; CAPSULES;

D O I：

10.1177/0091270010365557

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：444 / 451

页数：8

共 29 条

[1] Does inhibition of P-glycoprotein lead to drug-drug interactions? [J].

Balayssac, D ;

Authier, N ;

Cayre, A ;

Coudore, F .

TOXICOLOGY LETTERS, 2005, 156 (03) :319-329

[2] FOOD INTERACTION AND STEADY-STATE PHARMACOKINETICS OF ITRACONAZOLE CAPSULES IN HEALTHY MALE-VOLUNTEERS [J].

BARONE, JA ;

KOH, JG ;

BIERMAN, RH ;

COLAIZZI, JL ;

SWANSON, KA ;

GAFFAR, MC ;

MOSKOVITZ, BL ;

MECHLINSKI, W ;

VANDEVELDE, V .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (04) :778-784

[3] Enhanced bioavailability of itraconazole in hydroxypropyl-β-cyclodextrin solution versus capsules in healthy volunteers [J].

Barone, JA ;

Moskovitz, BL ;

Guarnieri, J ;

Hassell, AE ;

Colaizzi, JL ;

Bierman, RH ;

Jessen, L .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (07) :1862-1865

[4] Development and validation of a highly sensitive and robust LC-MS/MS with electrospray ionization method for simultaneous quantitation of itraconazole and hydroxyitraconazole in human plasma: Application to a bioequivalence study [J].

Bharathi, D. Vijaya ;

Hotha, Kishore Kumar ;

Sagar, P. V. Vidya ;

Kumar, Sanagapati Sirish ;

Reddy, Pandu Ranga ;

Naidu, A. ;

Mullangi, Ramesh .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2008, 868 (1-2) :70-76

[5]

Broderick Pamela, 2004, J Okla State Med Assoc, V97, P538

[6] EFFECTS OF AN ACIDIC BEVERAGE (COCA-COLA) ON ABSORPTION OF KETOCONAZOLE [J].

CHIN, TWF ;

LOEB, M ;

FONG, IW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (08) :1671-1675

[7] Pharmacology of itraconazole [J].

De Beule, K ;

Van Gestel, J .

DRUGS, 2001, 61 (Suppl 1) :27-37

[8]

Gaby AR, 2005, ALTERN MED REV, V10, P294

[9] The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin [J].

Greiner, B ;

Eichelbaum, M ;

Fritz, P ;

Kreichgauer, HP ;

Von Richter, O ;

Zundler, J ;

Kroemer, HK .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (02) :147-153

[10] Itraconazole - A reappraisal of its pharmacological properties and therapeutic use in the management of superficial fungal infections [J].

Haria, M ;

Bryson, HM ;

Goa, KL .

DRUGS, 1996, 51 (04) :585-620

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