Organic anions of pharmaceutical interest intercalated in magnesium aluminum LDHs by two different methods

Layered double hydroxides (LDHs) are a class of materials with increasing interest due to their singular properties, which make possible their application in a wide variety of fields. Because LDHs can intercalate anions within their interlayer region, they can be used in medicine as drug supports or matrices. Once encapsulated, the drug could be released at a rate dependent on the pH value. The aim of the present work was to intercalate a variety of anions of pharmaceutical interest, such as salicylate, citrate, glutamate and aspartate, using two different synthesis methods, a direct one (coprecipitation) and an indirect one (anion exchange of dodecylsulfate). The materials obtained were characterised by PXRD, simultaneous TG-DTA, chemical analysis and FT-IR spectroscopy. Furthermore, the buffer effect of the intercalated LDHs was evaluated.