Structure-activity relationships of vanillic acid ester analogs in inhibitory effect of antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells

被引：7
作者：
Ishimata, Nao [1 ]
Ito, Hideyuki [2 ]
Tai, Akihiro [1 ]
机构：
[1] Prefectural Univ Hiroshima, Fac Life & Environm Sci, 562 Nanatsuka Cho, Shobara, Hiroshima 7270023, Japan
[2] Okayama Prefectural Univ, Fac Hlth & Welf Sci, 111 Kuboki, Okayama 7191197, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 15期
关键词：
Structure-activity relationships; RBL-2H3; Vanillic acid ester; Degranulation; FC-EPSILON-RI; PERITONEAL MAST-CELLS; HISTAMINE-RELEASE; DERIVATIVES; METABOLISM; ACTIVATION; PARABENS; SERIES; MICE;
D O I：
10.1016/j.bmcl.2016.06.028
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Methyl vanillate (1) showed strong degranulation inhibitory activity among vanillin derivatives tested. In order to find structure-activity relationships for developing anti-allergic agents with simple structures and potent activity, we synthesized several vanillic acid (VA) ester derivatives with C-1-C-4 and C-8 alkyl chains and evaluated their degranulation inhibitory activities. The most active compound of VA ester derivatives was derivative 5 with a C-4 straight alkyl chain, and derivative 5 exhibited approximately three-fold greater inhibitory activity than that of 1. Moreover, we designed 8 types of analogs based on 5, and we found that the minimum structure for potent degranulation inhibitory activity requires direct connection of the butyl ester moiety on the benzene ring and at least one hydroxyl group on the benzene ring. Butyl meta or para hydroxyl benzoate (10 or 11) has a simpler structure than that of 5 and exhibited more potent degranulation inhibitory activity than that of 5. (C) 2016 Elsevier Ltd. All rights reserved.
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收藏
页码：3533 / 3536
页数：4
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