Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer

被引：50

作者：

Herrera-Vargas, Ana K. ^{[1
]}

Garcia-Rodriguez, Eduardo ^{[1
]}

Olea-Flores, Monserrat ^{[1
]}

Mendoza-Catalan, Miguel A. ^{[2
]}

Flores-Alfaro, Eugenia ^{[3
]}

Navarro-Tito, Napoleon ^{[1
]}

机构：

[1] Univ Autonoma Guerrero, Fac Ciencias Quim Biol, Lab Biol Celular Canc, Av Lazaro Cardenas S-N, Chilpancingo 39090, Gro, Mexico

[2] Univ Autonoma Guerrero, Fac Ciencias Quim Biol, Lab Biomed Mol, Chilpancingo 39090, Gro, Mexico

[3] Univ Autonoma Guerrero, Fac Ciencias Quim Biol, Lab Epidemiol Clin & Mol, Chilpancingo 39090, Gro, Mexico

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2021年 / 62卷

关键词：

Leptin; Angiogenesis; Vasculogenic mimicry; Tumor microenvironment; Cancer; HEPATOCYTE GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; INTUSSUSCEPTIVE ANGIOGENESIS; MATRIX METALLOPROTEINASES; MOLECULAR-MECHANISMS; VASCULAR MIMICRY; UP-REGULATION; FACTOR VEGF;

D O I：

10.1016/j.cytogfr.2021.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The acquired ability to induce the formation of a functional vasculature is a hallmark of cancer. Blood vessels in tumors are formed through various mechanisms, among the most important in cancer biology, angiogenesis, and vasculogenic mimicry have been described. Leptin is one of the main adipokines secreted by adipocytes in normal breast tissue and the tumor microenvironment. Here, we provide information on the relationship between leptin and the development of angiogenesis and vasculogenic mimicry in different types of cancer. Here, we report that leptin activates different pathways such as JAK-STAT3, MAPK/ERK, PKC, JNK, p38, and PI3K-Akt to induce the expression of various angiogenic factors and vasculogenic mimicry. In vivo models, leptin induces blood vessel formation through the PI3K-Akt-mTOR pathway. Interestingly, the relationship between leptin and vasculogenic mimicry was more significant in breast cancer. The information obtained suggests that leptin could be playing an essential role in tumor survival and metastasis through the induction of vascular mechanisms such as angiogenesis and vasculogenic mimicry; thus, leptin-induced pathways could be suggested as a promising therapeutic target.

引用

页码：23 / 41

页数：19

共 233 条

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