Mood correlates with blood serotonin, but not with glucose measures in patients with recurrent suicidal behavior

被引:11
作者
Verkes, RJ
Hengeveld, MW
van der Mast, RC
Fekkes, D
van Kempen, GMJ
机构
[1] Univ Nijmegen Hosp, Dept Psychiat, NL-6500 HB Nijmegen, Netherlands
[2] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands
[3] Psychiat Hosp Amsterdam, NL-1054 AG Amsterdam, Netherlands
[4] Erasmus Univ, Sect Pathophysiol Behav, NL-3000 DR Rotterdam, Netherlands
关键词
suicide attempts; depression; aggression; serotonin; glucose; platelets;
D O I
10.1016/S0165-1781(98)00075-4
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Depressive mood and impulsive-aggressive behavior are relevant to suicidal behavior and have been associated with decreased central serotonergic function. Impulsive behavior and aggression have also been related to abnormal glucose metabolism. To investigate these relationships further, blood serotonin (5-HT), blood glucose measures (glycated hemoglobin (HbA(1C)) and fructosamine) and self-reported depressive symptoms and anger were repeatedly measured, during a 1-year follow-up, in 106 patients who had recently attempted suicide for at least a second time. A major DSM-III-R Axis I diagnosis or use of antidepressants were reasons for exclusion. Intra-individual variations in blood 5-HT were inversely correlated with variations in depressive mood, self-depreciation, and anger, and positively with variations in fructosamine. Intra-individual variations of HbA(1C) or fructosamine were not correlated with mood. Mean blood 5-HT levels per patient were positively correlated with mean scores of depression and self-depreciation. The contrast between the intra-individual and the inter-individual correlations may reflect a difference between short- vs. long-term effects. The results do support an association between serotonergic function and mood, but not between glucose metabolism and mood, in recurrent suicide attempters. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:239 / 248
页数:10
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