Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension

被引:6
作者
Shihan, Mazen [1 ]
Novoyatleva, Tatyana [1 ]
Lehmeyer, Thilo [1 ]
Sydykov, Akylbek [1 ]
Schermuly, Ralph T. [1 ]
机构
[1] Justus Liebig Univ Giessen, Excellence Cluster Cardiopulm Inst CPI, Univ Giessen & Marburg Lung Ctr UGMLC, German Ctr Lung Res DZL, Aulweg 130, D-35392 Giessen, Germany
关键词
pulmonary arterial hypertension; purinergic P2Y2 receptor; pharmacological approach; P2Y(2) NUCLEOTIDE RECEPTOR; ENDOTHELIUM-DEPENDENT RELAXATION; DECREASES BLOOD-PRESSURE; VALVE INTERSTITIAL-CELLS; SHEAR-STRESS; ADENOSINE-TRIPHOSPHATE; NITRIC-OXIDE; INTRACELLULAR CA2+; CYSTIC-FIBROSIS; RENAL NA+;
D O I
10.3390/ijerph182111009
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Pulmonary arterial hypertension (PAH), group 1 pulmonary hypertension (PH), is a fatal disease that is characterized by vasoconstriction, increased pressure in the pulmonary arteries, and right heart failure. PAH can be described by abnormal vascular remodeling, hyperproliferation in the vasculature, endothelial cell dysfunction, and vascular tone dysregulation. The disease pathomechanisms, however, are as yet not fully understood at the molecular level. Purinergic receptors P2Y within the G-protein-coupled receptor family play a major role in fluid shear stress transduction, proliferation, migration, and vascular tone regulation in systemic circulation, but less is known about their contribution in PAH. Hence, studies that focus on purinergic signaling are of great importance for the identification of new therapeutic targets in PAH. Interestingly, the role of P2Y2 receptors has not yet been sufficiently studied in PAH, whereas the relevance of other P2Ys as drug targets for PAH was shown using specific agonists or antagonists. In this review, we will shed light on P2Y receptors and focus more on the P2Y2 receptor as a potential novel player in PAH and as a new therapeutic target for disease management.
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页数:20
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共 232 条
[1]   International union of pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy [J].
Abbracchio, Maria P. ;
Burnstock, Geoffrey ;
Boeynaems, Jean-Marie ;
Barnard, Eric A. ;
Boyer, Jose L. ;
Kennedy, Charles ;
Knight, Gillian E. ;
Fumagalli, Marta ;
Gachet, Christian ;
Jacobson, Kenneth A. ;
Weisman, Gary A. .
PHARMACOLOGICAL REVIEWS, 2006, 58 (03) :281-341
[2]   Denufosol Tetrasodium in Patients with Cystic Fibrosis and Normal to Mildly Impaired Lung Function [J].
Accurso, Frank J. ;
Moss, Richard B. ;
Wilmott, Robert W. ;
Anbar, Ran D. ;
Schaberg, Amy E. ;
Durham, Todd A. ;
Ramsey, Bonnie W. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 (05) :627-634
[3]   Development of a Novel Transgenic Rat Overexpressing the P2Y2 Nucleotide Receptor Using a Lentiviral Vector [J].
Agca, Cansu ;
Seye, Cheikh ;
Benson, Corinna M. Kashuba ;
Rikka, Shivaji ;
Chan, Anthony W. S. ;
Weisman, Gary A. ;
Agca, Yuksel .
JOURNAL OF VASCULAR RESEARCH, 2009, 46 (05) :447-458
[4]   Direct Evidence for P2Y2 Receptor Involvement in Vascular Response to Injury [J].
Agca, Yuksel ;
Qian, Shaomin ;
Agca, Cansu ;
Seye, Cheikh I. .
JOURNAL OF VASCULAR RESEARCH, 2016, 53 (3-4) :163-171
[5]   Extracellular ATP-mediated signaling for survival in Hyperoxia-induced oxidative stress [J].
Ahmad, S ;
Ahmad, A ;
Ghosh, M ;
Leslie, CC ;
White, CW .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (16) :16317-16325
[6]   Purinergic signaling and kinase activation for survival in pulmonary oxidative stress and disease [J].
Ahmad, Shama ;
Ahmad, Aftab ;
White, Carl W. .
FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (01) :29-40
[7]   Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation [J].
Albarran-Juarez, Julian ;
Iring, Andras ;
Wang, ShengPeng ;
Joseph, Sayali ;
Grimm, Myriam ;
Strilic, Boris ;
Wettschureck, Nina ;
Althoff, Till F. ;
Offermanns, Stefan .
JOURNAL OF EXPERIMENTAL MEDICINE, 2018, 215 (10) :2655-2672
[8]   P2Y11 Purinoceptor Mediates the ATP-Enhanced Chemotactic Response of Rat Neutrophils [J].
Alkayed, Feras ;
Kashimata, Masanori ;
Koyama, Noriko ;
Hayashi, Toru ;
Tamura, Yasuo ;
Azuma, Yukio .
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 120 (04) :288-295
[9]   Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries [J].
Alsaqati, M. ;
Chan, S. L. F. ;
Ralevic, V. .
PURINERGIC SIGNALLING, 2014, 10 (02) :241-249
[10]   Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension [J].
Amirjanians, Matthieu ;
Egemnazarov, Bakytbek ;
Sydykov, Akylbek ;
Kojonazarov, Baktybek ;
Brandes, Ralf ;
Luitel, Himal ;
Pradhan, Kabita ;
Stasch, Johannes-Peter ;
Redlich, Gorden ;
Weissmann, Norbert ;
Grimminger, Friedrich ;
Seeger, Werner ;
Ghofrani, Hossein ;
Schermuly, Ralph .
ONCOTARGET, 2017, 8 (18) :29613-29624