A Highly Regio- and Stereoselective Cascade Annulation of Enals and Benzodi(enone)s Catalyzed by N-Heterocyclic Carbenes

被引：81

作者：

Fang, Xinqiang ^{[1
]}

Jiang, Kun ^{[1
]}

Xing, Chong ^{[1
]}

Hao, Lin ^{[1
]}

Chi, Yonggui Robin ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

cascade reactions; enal activation; N-heterocyclic carbenes; organocatalysis; synthetic methods; ALPHA; BETA-UNSATURATED ALDEHYDES; EFFICIENT SYNTHESIS; ALDER REACTIONS; HOMOENOLATE; UMPOLUNG; CONSTRUCTION; GENERATION; CONVERSION; CHALCONES; ESTERS;

D O I：

10.1002/anie.201007144

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three stereogenic centers in a row: The unconventional activation of enal compounds mediated by an N-heterocyclic carbene (NHC) has generated three consecutive reactive carbon centers that undergo highly regio- and stereoselective annulations with di(enone)s to generate benzotricyclic products containing multiple stereogenic centers (see scheme). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1910 / 1913

页数：4

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