Etoposide, cisplatin, epirubicin chemotherapy in the treatment of pediatric liver tumors

被引：4

作者：

Casanova, M ^{[1
]}

Massimino, M ^{[1
]}

Ferrari, A ^{[1
]}

Spreafico, F ^{[1
]}

Piva, L ^{[1
]}

Coppa, J ^{[1
]}

Luksch, R ^{[1
]}

Cefalo, G ^{[1
]}

Terenziani, M ^{[1
]}

Polastri, D ^{[1
]}

Bellani, FF ^{[1
]}

Mazzaferro, V ^{[1
]}

机构：

[1] Ist Nazl Tumori, Pediat Oncol Unit, I-20133 Milan, Italy

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2005年 / 22卷 / 03期

关键词：

chemotherapy; cis platin; epirubicin; etoposide; hepatoblastoma; hepatocellular carcinoma;

D O I：

10.1080/08880010590921441

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To discuss the potential benefit of a chemotherapy regimen including etoposide ( etoposide, cis-platin, epirubicin [EPE]), the authors report a single-institutional experience regarding 13 children with hepatoblastoma (HB) and 7 with hepatocellular carcinoma (HCC). Chemotherapy achieved partial response in 8/9 HB and in 4/5 HCC. Eight initially unresectable HB subsequently had liver resection. Event-free survival and overall survival at 5 years were 84 and 88% for HB (nonmetastatic cases: 91 and 100%), 29% for HCC. EPE chemotherapy seems to be effective in the treatment of childhood malignant liver tumors. Etoposide could be suggested as part of intensive multidrug regimens for HCC and high-risk HB.

引用

页码：189 / 198

页数：10

共 17 条

[1] Hepatocellular carcinoma in children: Results of the first prospective study of the International Society of Pediatric Oncology Group [J].

Czauderna, P ;

Mackinlay, G ;

Perilongo, G ;

Brown, J ;

Shafford, E ;

Aronson, D ;

Pritchard, J ;

Chapchap, P ;

Keeling, J ;

Plaschkes, J ;

Otte, JB .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (12) :2798-2804

[2] Epidemiology of primary hepatic malignancies in US children [J].

Darbari, A ;

Sabin, KM ;

Shapiro, CN ;

Schwarz, KB .

HEPATOLOGY, 2003, 38 (03) :560-566

[3]

EVANS AE, 1982, CANCER-AM CANCER SOC, V50, P821, DOI 10.1002/1097-0142(19820901)50:5<821::AID-CNCR2820500502>3.0.CO

[4]

2-K

[5]

FOSSATIBELLANI F, 1993, J SURG ONCOL S3, V3, P119

[6]

Fuchs J, 1999, MED PEDIATR ONCOL, V32, P209, DOI 10.1002/(SICI)1096-911X(199903)32:3<209::AID-MPO8>3.3.CO

[7]

2-S

[8]

Fuchs J, 1998, CANCER-AM CANCER SOC, V83, P2400, DOI 10.1002/(SICI)1097-0142(19981201)83:11<2400::AID-CNCR21>3.0.CO

[9]

2-6

[10] Pretreatment prognostic factors and treatment results in children with hepatoblastoma -: A report from the German Cooperative Pediatric Liver Tumor Study HB 94 [J].

Fuchs, J ;

Rydzynski, J ;

Von Schweinitz, D ;

Bode, U ;

Hecker, H ;

Weinel, P ;

Bürger, D ;

Harms, D ;

Erttmann, R ;

Oldhafer, K ;

Mildenberger, H .

CANCER, 2002, 95 (01) :172-182

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